Prxl2b peroxiredoxin like 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prxl2bprovided by RGD
Official Full Name: peroxiredoxin like 2Bprovided by RGD
Primary source: RGD:1308251
See related: EnsemblRapid:ENSRNOG00000085951 AllianceGenome:RGD:1308251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam213b; RGD1308251
Summary: Predicted to enable prostaglandin F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in myelin sheath. Orthologous to human PRXL2B (peroxiredoxin like 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 298.2), Kidney (RPKM 237.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (170744953..170747556, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (165462610..165465213, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (172304799..172307402, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables prostaglandin F synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin F synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin F synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostamide/prostaglandin F synthase

Names: family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase

NP_001102167.1

EC 1.11.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108697.1 → NP_001102167.1 prostamide/prostaglandin F synthase

See identical proteins and their annotated locations for NP_001102167.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/Swiss-Prot

D3ZVR7

Related

ENSRNOP00000107860.1, ENSRNOT00000146374.1

Conserved Domains (1) summary

cd02970
Location:8 → 164

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...