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    Itgb3bp integrin subunit beta 3 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362548, updated on 2-Nov-2024

    Summary

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    Symbol
    Itgb3bpprovided by RGD
    Full Name
    integrin subunit beta 3 binding proteinprovided by RGD
    Primary source
    RGD:1310044
    See related
    EnsemblRapid:ENSRNOG00000009116 AllianceGenome:RGD:1310044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including CENP-A containing chromatin assembly; apoptotic process; and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of epithelial cell apoptotic process and positive regulation of epithelial cell proliferation. Predicted to be located in kinetochore. Predicted to be part of inner kinetochore. Predicted to be active in nucleoplasm. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 108.4), Thymus (RPKM 66.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itgb3bp in Genome Data Viewer
    Location:
    5q33
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119575657..119640974, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114460217..114525538, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118476410..118541928, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556374 Neighboring gene forkhead box D3 Neighboring gene uncharacterized LOC134479015 Neighboring gene ALG6, alpha-1,3-glucosyltransferase Neighboring gene EF-hand calcium binding domain 7 Neighboring gene phosphoglucomutase 1 Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene RNA, U6 small nuclear 233

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein R
    Names
    CENP-R
    beta3-endonexin
    integrin beta 3 binding protein (beta3-endonexin)
    nuclear receptor-interacting factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013213.1 → NP_001013231.1  centromere protein R

      See identical proteins and their annotated locations for NP_001013231.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086363
      UniProtKB/Swiss-Prot
      Q5U1Z7
      UniProtKB/TrEMBL
      A0A0G2K8A1, A6JRM1
      Related
      ENSRNOP00000012947.6, ENSRNOT00000012947.7
      Conserved Domains (1) summary
      pfam06729
      Location:27 → 162
      CENP-R; Kinetochore component, CENP-R

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      119575657..119640974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110271.2 → XP_038966199.1  centromere protein R isoform X2

      Conserved Domains (1) summary
      pfam06729
      Location:123 → 259
      CENP-R; Kinetochore component, CENP-R

    2. XM_039110272.2 → XP_038966200.1  centromere protein R isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARY4
      Related
      ENSRNOP00000094591.1, ENSRNOT00000103428.2
      Conserved Domains (1) summary
      pfam06729
      Location:123 → 259
      CENP-R; Kinetochore component, CENP-R

    3. XM_017593484.3 → XP_017448973.1  centromere protein R isoform X11

      UniProtKB/TrEMBL
      A0A0G2K8A1, A0A8L2Q6X3
      Related
      ENSRNOP00000101174.1, ENSRNOT00000144538.1

    4. XM_063287953.1 → XP_063144023.1  centromere protein R isoform X6

      Related
      ENSRNOP00000100095.1, ENSRNOT00000135761.1

    5. XM_063287950.1 → XP_063144020.1  centromere protein R isoform X1

    6. XM_063287958.1 → XP_063144028.1  centromere protein R isoform X10

    7. XM_063287954.1 → XP_063144024.1  centromere protein R isoform X7

    8. XM_063287952.1 → XP_063144022.1  centromere protein R isoform X5

    9. XM_063287962.1 → XP_063144032.1  centromere protein R isoform X13

    10. XM_063287964.1 → XP_063144034.1  centromere protein R isoform X13

    11. XM_063287959.1 → XP_063144029.1  centromere protein R isoform X10

    12. XM_063287960.1 → XP_063144030.1  centromere protein R isoform X10

    13. XM_063287951.1 → XP_063144021.1  centromere protein R isoform X4

    14. XM_063287967.1 → XP_063144037.1  centromere protein R isoform X13

    15. XM_063287965.1 → XP_063144035.1  centromere protein R isoform X13

    16. XM_063287963.1 → XP_063144033.1  centromere protein R isoform X13

    17. XM_063287957.1 → XP_063144027.1  centromere protein R isoform X9

    18. XM_063287961.1 → XP_063144031.1  centromere protein R isoform X12

    19. XM_063287955.1 → XP_063144025.1  centromere protein R isoform X8

    RNA

    1. XR_005504482.2 RNA Sequence

    2. XR_005504480.2 RNA Sequence

    3. XR_005504481.2 RNA Sequence

    4. XR_010066419.1 RNA Sequence

    5. XR_010066417.1 RNA Sequence

    6. XR_010066418.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1Z7.1 GenPept UniProtKB/Swiss-Prot:Q5U1Z7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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