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    Alg6 ALG6, alpha-1,3-glucosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362547, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alg6provided by RGD
    Official Full Name
    ALG6, alpha-1,3-glucosyltransferaseprovided by RGD
    Primary source
    RGD:1308815
    See related
    EnsemblRapid:ENSRNOG00000009045 AllianceGenome:RGD:1308815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 51.9), Kidney (RPKM 51.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg6 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119520415..119606365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114404972..114454440)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118415680..118470634)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556374 Neighboring gene forkhead box D3 Neighboring gene uncharacterized LOC134479015 Neighboring gene integrin subunit beta 3 binding protein Neighboring gene EF-hand calcium binding domain 7 Neighboring gene phosphoglucomutase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic. Westphal V, et al. Mol Genet Metab, 2000 Jul. PMID 10924277
    2. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. Imbach T, et al. Proc Natl Acad Sci U S A, 1999 Jun 8. PMID 10359825, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC124652

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
    Names
    asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
    asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)
    asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog
    asparagine-linked glycosylation protein 6 homolog
    dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
    dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
    NP_001028881.1
    XP_038966196.1
    XP_038966197.1
    XP_063144018.1
    XP_063144019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033709.1 → NP_001028881.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

      See identical proteins and their annotated locations for NP_001028881.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101850
      UniProtKB/Swiss-Prot
      Q3T1L5
      UniProtKB/TrEMBL
      F1LMD6
      Related
      ENSRNOP00000093347.2, ENSRNOT00000107656.2
      Conserved Domains (1) summary
      pfam03155
      Location:32 → 485
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      119520415..119606365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287948.1 → XP_063144018.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

    2. XM_063287949.1 → XP_063144019.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

      Related
      ENSRNOP00000109337.1, ENSRNOT00000133198.1

    3. XM_039110268.1 → XP_038966196.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

      UniProtKB/TrEMBL
      F1LMD6
      Related
      ENSRNOP00000012052.9, ENSRNOT00000012052.9
      Conserved Domains (1) summary
      pfam03155
      Location:98 → 521
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    4. XM_039110269.2 → XP_038966197.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

      Conserved Domains (1) summary
      cl21590
      Location:98 → 371
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T1L5.1 GenPept UniProtKB/Swiss-Prot:Q3T1L5

    Gene LinkOut

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