Parp12 poly (ADP-ribose) polymerase family, member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp12provided by RGD
Official Full Name: poly (ADP-ribose) polymerase family, member 12provided by RGD
Primary source: RGD:1308628
See related: EnsemblRapid:ENSRNOG00000008196 AllianceGenome:RGD:1308628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zc3hdc1
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 102.2), Spleen (RPKM 95.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (68793411..68851214, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (67826548..67885356, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (66835647..66900324, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP12

Names: poly ADP-ribose polymerase 12; zinc finger CCCH type domain containing 1

NP_001102093.2

EC 2.4.2.30

XP_006236408.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108623.2 → NP_001102093.2 protein mono-ADP-ribosyltransferase PARP12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IET7, D4A3V3

Related

ENSRNOP00000011481.6, ENSRNOT00000011481.8

Conserved Domains (5) summary

smart00356
Location:183 → 205

ZnF_C3H1; zinc finger

cd01439
Location:566 → 682

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam02825
Location:382 → 463

WWE; WWE domain

pfam18606
Location:12 → 74

HTH_53; Zap helix turn helix N-terminal domain

cl02729
Location:304 → 377

WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

68793411..68851214 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236346.5 → XP_006236408.1 protein mono-ADP-ribosyltransferase PARP12 isoform X1

See identical proteins and their annotated locations for XP_006236408.1

Conserved Domains (4) summary

smart00356
Location:183 → 205

ZnF_C3H1; zinc finger

pfam02825
Location:382 → 463

WWE; WWE domain

cl00283
Location:566 → 598

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

cl02729
Location:304 → 377

WWE; WWE domain