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    Abcb8 ATP binding cassette subfamily B member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362302, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Abcb8provided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 8provided by RGD
    Primary source
    RGD:1307655
    See related
    EnsemblRapid:ENSRNOG00000008557 AllianceGenome:RGD:1307655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MITOSUR
    Summary
    Predicted to enable ABC-type peptide transporter activity and ATP binding activity. Predicted to be involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane; nucleolus; and nucleoplasm. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Predicted to be active in membrane and mitochondrion. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 85.6), Heart (RPKM 85.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abcb8 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11660716..11676030, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10766206..10783598, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7296538..7311856, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 5 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene uncharacterized LOC120102208 Neighboring gene autophagy related 9B Neighboring gene nitric oxide synthase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis. Melaine N, et al. Int J Androl, 2006 Jun. PMID 16390497
    2. Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. Hogue DL, et al. J Mol Biol, 1999 Jan 8. PMID 9878413
    3. Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Ichikawa Y, et al. Proc Natl Acad Sci U S A, 2012 Mar 13. PMID 22375032, Free PMC Article
    4. Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, et al. Nature, 2019 Aug. PMID 31435016, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins.
      Title: Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
    2. In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes).
      Title: Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93731

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type peptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial ATP-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial ATP-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial ATP-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial potassium channel ATP-binding subunit
    Names
    ABC transporter 8
    ATP-binding cassette sub-family B member 8, mitochondrial
    ATP-binding cassette, sub-family B (MDR/TAP), member 8
    ATP-binding cassette, sub-family B, member 8
    ATP-binding cassette, subfamily B (MDR/TAP), member 8
    mitochondrial sulfonylurea-receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007796.2 → NP_001007797.1  mitochondrial potassium channel ATP-binding subunit precursor

      See identical proteins and their annotated locations for NP_001007797.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q0QVT4, Q5RKI8
      UniProtKB/TrEMBL
      A0A0H2UHH3
      Related
      ENSRNOP00000012222.5, ENSRNOT00000012222.8
      Conserved Domains (1) summary
      COG1132
      Location:116 → 695
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11660716..11676030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107751.2 → XP_038963679.1  mitochondrial potassium channel ATP-binding subunit isoform X4

      Conserved Domains (1) summary
      COG1132
      Location:18 → 456
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

    2. XM_006235946.4 → XP_006236008.1  mitochondrial potassium channel ATP-binding subunit isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHH3
      Conserved Domains (3) summary
      cd03249
      Location:334 → 572
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:16 → 575
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:16 → 287
      ABC_membrane; ABC transporter transmembrane region

    3. XM_039107752.2 → XP_038963680.1  mitochondrial potassium channel ATP-binding subunit isoform X5

      Conserved Domains (3) summary
      cd03249
      Location:188 → 426
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      cd07346
      Location:7 → 56
      ABC_6TM_exporters; TM helix 4 [structural motif]
      cl38913
      Location:2 → 161
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters

    4. XM_063286229.1 → XP_063142299.1  mitochondrial potassium channel ATP-binding subunit isoform X3

    5. XM_063286228.1 → XP_063142298.1  mitochondrial potassium channel ATP-binding subunit isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKI8.1 GenPept UniProtKB/Swiss-Prot:Q5RKI8

    Gene LinkOut

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