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    Gle1 GLE1 RNA export mediator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362098, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gle1provided by RGD
    Official Full Name
    GLE1 RNA export mediatorprovided by RGD
    Primary source
    RGD:1307329
    See related
    AllianceGenome:RGD:1307329
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gle1l
    Summary
    Predicted to enable several functions, including identical protein binding activity; inositol hexakisphosphate binding activity; and translation initiation factor binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 121.2), Spleen (RPKM 86.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gle1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33607160..33638879)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13209312..13237018)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8498098..8530218)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene spectrin, alpha, non-erythrocytic 1 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene Set nuclear proto-oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Jao LE, et al. Mol Biol Cell, 2017 Jan 1. PMID 28035044, Free PMC Article
    2. Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease. Folkmann AW, et al. Cell, 2013 Oct 24. PMID 24243016, Free PMC Article
    3. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ, et al. Trends Cell Biol, 2013 Aug. PMID 23583578, Free PMC Article
    4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116182

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mRNA export factor GLE1
    Names
    GLE1 RNA export mediator homolog
    GLE1 RNA export mediator-like (yeast
    GLE1-like protein
    nucleoporin GLE1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025731.1 → NP_001020902.1  mRNA export factor GLE1

      See identical proteins and their annotated locations for NP_001020902.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099088
      UniProtKB/Swiss-Prot
      Q4KLN4
      UniProtKB/TrEMBL
      A0A8I6GL68, A6JTT7
      Conserved Domains (1) summary
      pfam07817
      Location:409 → 647
      GLE1; GLE1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33607160..33638879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233836.5 → XP_006233898.1  mRNA export factor GLE1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4N4, A0A8I6G464
      Conserved Domains (1) summary
      pfam07817
      Location:409 → 647
      GLE1; GLE1-like protein

    RNA

    1. XR_010064653.1 RNA Sequence

    2. XR_010064649.1 RNA Sequence

    3. XR_010064651.1 RNA Sequence

    4. XR_010064650.1 RNA Sequence

    5. XR_010064652.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLN4.1 GenPept UniProtKB/Swiss-Prot:Q4KLN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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