Sike1 suppressor of IKBKE 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sike1provided by RGD
Official Full Name: suppressor of IKBKE 1provided by RGD
Primary source: RGD:1311316
See related: EnsemblRapid:ENSRNOG00000017502 AllianceGenome:RGD:1311316
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sike; RGD1311316
Summary: Predicted to enable protein kinase binding activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Predicted to be involved in negative regulation of hippo signaling. Predicted to be located in cytoplasm. Predicted to be part of FAR/SIN/STRIPAK complex. Orthologous to human SIKE1 (suppressor of IKBKE 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 120.6), Heart (RPKM 120.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (193206490..193214321)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (190518002..190525833)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (205488182..205496013)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH129234 (e-PCR)
- UniSTS:212542

RH131841 (e-PCR)
- UniSTS:215124

BE102137 (e-PCR)
- UniSTS:260692

RH129266 (e-PCR)
- UniSTS:212573

RH127374 (e-PCR)
- UniSTS:210684

RH140858 (e-PCR)
- UniSTS:210684

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of IKBKE 1

Names: suppressor of IKK-epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.