Them4 thioesterase superfamily member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Them4provided by RGD
Official Full Name: thioesterase superfamily member 4provided by RGD
Primary source: RGD:1304723
See related: EnsemblRapid:ENSRNOG00000020829 AllianceGenome:RGD:1304723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304723
Summary: Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in cytosol and mitochondrion. Orthologous to human THEM4 (thioesterase superfamily member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 109.8), Brain (RPKM 84.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (184642603..184663752)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (181953550..181974708)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (195554092..195576710)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTMP is important in the neurodegeneration that is associated with stroke and identify CTMP as a therapeutic target for the amelioration of hippocampal injury and cognitive deficits.
Title: The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase THEM4

Names: acyl-CoA thioesterase THEM4

NP_001020188.1

EC 3.1.2.2

XP_038958621.1

EC 3.1.2.2

XP_038958622.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025017.1 → NP_001020188.1 acyl-coenzyme A thioesterase THEM4

See identical proteins and their annotated locations for NP_001020188.1

Status: PROVISIONAL

Source sequence(s)

BC093385

UniProtKB/Swiss-Prot

Q566R0

UniProtKB/TrEMBL

A0A8I5ZSX8, A6K2P9

Related

ENSRNOP00000028260.5, ENSRNOT00000028260.8

Conserved Domains (1) summary

cd03443
Location:110 → 221

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

184642603..184663752

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102693.2 → XP_038958621.1 acyl-coenzyme A thioesterase THEM4 isoform X1

Conserved Domains (1) summary

cd03443
Location:55 → 166

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...
XM_039102694.2 → XP_038958622.1 acyl-coenzyme A thioesterase THEM4 isoform X1

Conserved Domains (1) summary

cd03443
Location:55 → 166

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...