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    Vps26a VPS26 retromer complex component A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361846, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vps26aprovided by RGD
    Official Full Name
    VPS26 retromer complex component Aprovided by RGD
    Primary source
    RGD:1359254
    See related
    EnsemblRapid:ENSRNOG00000030683 AllianceGenome:RGD:1359254
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vps26
    Summary
    Predicted to be involved in endocytic recycling; intracellular protein transport; and retrograde transport, endosome to Golgi. Located in cytosol. Part of retromer complex. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 233.2), Heart (RPKM 155.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps26a in Genome Data Viewer
    Location:
    20q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30947018..30976964, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30404320..30434266, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32085465..32115310, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene hexokinase domain containing 1 Neighboring gene Suv3 like RNA helicase Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC108353232 Neighboring gene serglycin Neighboring gene large ribosomal subunit protein eL39-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats. Lin TB, et al. J Neurosci, 2015 Nov 4. PMID 26538661, Free PMC Article
    2. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, et al. Sci Rep, 2017 Aug 18. PMID 28821857, Free PMC Article
    3. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. Arighi CN, et al. J Cell Biol, 2004 Apr. PMID 15078903, Free PMC Article
    4. Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Collins BM, et al. Nat Struct Mol Biol, 2005 Jul. PMID 15965486
    5. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Temkin P, et al. Nat Cell Biol, 2011 Jun. PMID 21602791, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VPS26A-SNX27 interaction plays a role in the development of neuropathic pain.
      Title: VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94168

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytic recycling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer, cargo-selective complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer, cargo-selective complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tubular endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in tubular endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tubular endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 26A
    Names
    H beta 58
    VPS26 retromer complex comonent A
    vacuolar protein sorting 26 homolog A
    vacuole protein sorting 26
    vesicle protein sorting 26A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007740.1 → NP_001007741.1  vacuolar protein sorting-associated protein 26A

      See identical proteins and their annotated locations for NP_001007741.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079150
      UniProtKB/Swiss-Prot
      Q6AY86
      UniProtKB/TrEMBL
      A0A0G2JXT0, A6K446
      Related
      ENSRNOP00000070391.3, ENSRNOT00000081916.3
      Conserved Domains (1) summary
      pfam03643
      Location:8 → 283
      Vps26; Vacuolar protein sorting-associated protein 26

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      30947018..30976964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279302.1 → XP_063135372.1  vacuolar protein sorting-associated protein 26A isoform X3

    2. XM_039098876.2 → XP_038954804.1  vacuolar protein sorting-associated protein 26A isoform X5

      Conserved Domains (1) summary
      pfam03643
      Location:9 → 163
      Vps26; Vacuolar protein sorting-associated protein 26

    3. XM_006256460.5 → XP_006256522.1  vacuolar protein sorting-associated protein 26A isoform X1

      See identical proteins and their annotated locations for XP_006256522.1

      UniProtKB/TrEMBL
      A0A0G2JXT0, A0A8L2QWS2, A6K447
      Related
      ENSRNOP00000062170.2, ENSRNOT00000067883.4
      Conserved Domains (1) summary
      pfam03643
      Location:40 → 315
      Vps26; Vacuolar protein sorting-associated protein 26

    4. XM_039098875.2 → XP_038954803.1  vacuolar protein sorting-associated protein 26A isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXT0
      Conserved Domains (1) summary
      pfam03643
      Location:40 → 275
      Vps26; Vacuolar protein sorting-associated protein 26

    5. XM_017601692.2 → XP_017457181.1  vacuolar protein sorting-associated protein 26A isoform X4

      UniProtKB/TrEMBL
      A6K449
      Conserved Domains (1) summary
      pfam03643
      Location:2 → 172
      Vps26; Vacuolar protein sorting-associated protein 26
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY86.1 GenPept UniProtKB/Swiss-Prot:Q6AY86

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