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    C18h18orf54 similar to human chromosome 18 open reading frame 54 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361346, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C18h18orf54provided by RGD
    Official Full Name
    similar to human chromosome 18 open reading frame 54provided by RGD
    Primary source
    RGD:1563837
    See related
    EnsemblRapid:ENSRNOG00000028677 AllianceGenome:RGD:1563837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Las2
    Summary
    Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human C18orf54 (chromosome 18 open reading frame 54). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 126.6), Testes (RPKM 122.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C18h18orf54 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (66340567..66364831, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64065125..64090260, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68957542..68984087, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene dynactin associated protein Neighboring gene uncharacterized LOC134482986 Neighboring gene StAR-related lipid transfer domain containing 6 Neighboring gene DNA polymerase iota Neighboring gene uncharacterized LOC134483047 Neighboring gene methyl-CpG binding domain protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Liu PY, et al. Cancer Res, 2009 Aug 1. PMID 19622765
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lung adenoma susceptibility protein 2 homolog
    Names
    uncharacterized protein C18orf54 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017462.2 → NP_001017462.1  lung adenoma susceptibility protein 2 homolog isoform 2 precursor

      See identical proteins and their annotated locations for NP_001017462.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q66H35
      UniProtKB/TrEMBL
      A0A8L2UIV9
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 230
      LAS2; Lung adenoma susceptibility protein 2

    2. NM_001398664.1 → NP_001385593.1  lung adenoma susceptibility protein 2 homolog isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6GFU5
      Related
      ENSRNOP00000087271.1, ENSRNOT00000109976.2
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 232
      LAS2; Lung adenoma susceptibility protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      66340567..66364831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096987.2 → XP_038952915.1  lung adenoma susceptibility protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIR2
      Related
      ENSRNOP00000014670.8, ENSRNOT00000014670.9
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 232
      LAS2; Lung adenoma susceptibility protein 2

    2. XM_039096989.2 → XP_038952917.1  lung adenoma susceptibility protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam15792
      Location:44 → 115
      LAS2; Lung adenoma susceptibility protein 2

    3. XM_017601003.3 → XP_017456492.2  lung adenoma susceptibility protein 2 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIR2
      Conserved Domains (1) summary
      pfam15792
      Location:161 → 232
      LAS2; Lung adenoma susceptibility protein 2

    RNA

    1. XR_596979.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H35.1 GenPept UniProtKB/Swiss-Prot:Q66H35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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