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    Tmem170b transmembrane protein 170B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361230, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem170bprovided by RGD
    Official Full Name
    transmembrane protein 170Bprovided by RGD
    Primary source
    RGD:1561506
    See related
    EnsemblRapid:ENSRNOG00000031495 AllianceGenome:RGD:1561506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM170B (transmembrane protein 170B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 148.7), Brain (RPKM 116.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem170b in Genome Data Viewer
    Location:
    17p12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23336914..23375707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23131151..23169946, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22832641..22863966, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene uncharacterized LOC120097814 Neighboring gene uncharacterized LOC134482837 Neighboring gene neural precursor cell expressed, developmentally down-regulated 9 Neighboring gene uncharacterized LOC134482836

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway. Li M, et al. Cell Death Dis, 2018 Jan 24. PMID 29367600, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 170B
    Names
    Ac1258
    liver regeneration-related protein LRRG102

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008774.2 → NP_001008774.2  transmembrane protein 170B

      See identical proteins and their annotated locations for NP_001008774.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q7TQ79
      Related
      ENSRNOP00000047176.3, ENSRNOT00000046157.6
      Conserved Domains (1) summary
      pfam10190
      Location:28 → 132
      Tmemb_170; Putative transmembrane protein 170

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      23336914..23375707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095875.2 → XP_038951803.1  transmembrane protein 170B isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARP2
      Related
      ENSRNOP00000108575.1, ENSRNOT00000123299.1
      Conserved Domains (1) summary
      pfam10190
      Location:31 → 75
      Tmemb_170; Putative transmembrane protein 170
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQ79.2 GenPept UniProtKB/Swiss-Prot:Q7TQ79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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