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    Stimate STIM activating enhancer [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361110, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stimateprovided by RGD
    Official Full Name
    STIM activating enhancerprovided by RGD
    Primary source
    RGD:735152
    See related
    EnsemblRapid:ENSRNOG00000017051 AllianceGenome:RGD:735152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem110
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in activation of store-operated calcium channel activity and store-operated calcium entry. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Orthologous to several human genes including STIMATE (STIM activating enhancer). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 82.5), Thymus (RPKM 77.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stimate in Genome Data Viewer
    Location:
    16p16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6019788..6077272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6013392..6070829)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6903212..6958786)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthase, pseudogene 1 Neighboring gene Scm-like with four mbt domains 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene uncharacterized LOC102555619 Neighboring gene uncharacterized LOC134482447 Neighboring gene musculoskeletal, embryonic nuclear protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108529

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of store-operated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in store-operated calcium entry IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in store-operated calcium entry ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    store-operated calcium entry regulator STIMATE
    Names
    STIM-activating enhancer encoded by TMEM110
    transmembrane protein 110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198774.2 → NP_942069.1  store-operated calcium entry regulator STIMATE

      See identical proteins and their annotated locations for NP_942069.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088092
      UniProtKB/Swiss-Prot
      Q7TSW6
      UniProtKB/TrEMBL
      A0A8I5ZKL5, A6KG24
      Related
      ENSRNOP00000023314.4, ENSRNOT00000023314.6
      Conserved Domains (1) summary
      pfam12400
      Location:100 → 219
      STIMATE; STIMATE family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6019788..6077272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275492.1 → XP_063131562.1  store-operated calcium entry regulator STIMATE isoform X2

    2. XM_039094618.2 → XP_038950546.1  store-operated calcium entry regulator STIMATE isoform X1

      Conserved Domains (1) summary
      pfam12400
      Location:20 → 139
      STIMATE; STIMATE family

    3. XM_063275491.1 → XP_063131561.1  store-operated calcium entry regulator STIMATE isoform X1

    4. XM_063275490.1 → XP_063131560.1  store-operated calcium entry regulator STIMATE isoform X1

    RNA

    1. XR_010058297.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSW6.1 GenPept UniProtKB/Swiss-Prot:Q7TSW6

    Gene LinkOut

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