U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dusp29 dual specificity phosphatase 29 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361003, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dusp29provided by RGD
    Official Full Name
    dual specificity phosphatase 29provided by RGD
    Primary source
    RGD:1310229
    See related
    EnsemblRapid:ENSRNOG00000013034 AllianceGenome:RGD:1310229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dupd1
    Summary
    Predicted to enable MAP kinase phosphatase activity; protein homodimerization activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including glucose homeostasis; negative regulation of ERK1 and ERK2 cascade; and protein dephosphorylation. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human DUSP29 (dual specificity phosphatase 29). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 145.9) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dusp29 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2642809..2682850)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2593473..2634019)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2766929..2806573)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352868 Neighboring gene uncharacterized LOC120096899 Neighboring gene dual specificity phosphatase 13B Neighboring gene uncharacterized LOC108352871 Neighboring gene lysine acetyltransferase 6B Neighboring gene uncharacterized LOC134482074 Neighboring gene uncharacterized LOC102553460

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution. Lountos GT, et al. Acta Crystallogr D Biol Crystallogr, 2011 May. PMID 21543850, Free PMC Article
    2. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. Friedberg I, et al. FEBS Lett, 2007 May 29. PMID 17498703
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dual specificity phosphatase 29
    Names
    dual specificity phosphatase DUPD1
    dual specificity phosphatase and pro isomerase domain containing 1
    NP_001101838.1
    XP_017455221.1
    XP_063130436.1
    XP_063130437.1
    XP_063130438.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108368.1 → NP_001101838.1  dual specificity phosphatase 29

      See identical proteins and their annotated locations for NP_001101838.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474061
      UniProtKB/Swiss-Prot
      P0C595
      UniProtKB/TrEMBL
      A6KKS6
      Related
      ENSRNOP00000017483.4, ENSRNOT00000017483.7
      Conserved Domains (1) summary
      cd14575
      Location:44 → 203
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      2642809..2682850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274368.1 → XP_063130438.1  dual specificity phosphatase 29 isoform X3

    2. XM_063274366.1 → XP_063130436.1  dual specificity phosphatase 29 isoform X1

      UniProtKB/Swiss-Prot
      P0C595
      UniProtKB/TrEMBL
      A6KKS6

    3. XM_017599732.3 → XP_017455221.1  dual specificity phosphatase 29 isoform X1

      UniProtKB/Swiss-Prot
      P0C595
      UniProtKB/TrEMBL
      A6KKS6
      Conserved Domains (1) summary
      cd14575
      Location:44 → 203
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

    4. XM_063274367.1 → XP_063130437.1  dual specificity phosphatase 29 isoform X2

      Related
      ENSRNOP00000110191.1, ENSRNOT00000124521.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C595.1 GenPept UniProtKB/Swiss-Prot:P0C595

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools