Etnk2 ethanolamine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etnk2provided by RGD
Official Full Name: ethanolamine kinase 2provided by RGD
Primary source: RGD:1305304
See related: EnsemblRapid:ENSRNOG00000028368 AllianceGenome:RGD:1305304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EKI 2
Summary: Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process and phosphorylation. Predicted to act upstream of or within in utero embryonic development; placenta development; and post-embryonic development. Predicted to be active in cytoplasm. Orthologous to human ETNK2 (ethanolamine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 399.6), Adrenal (RPKM 141.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (47362964..47381100)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (44811012..44829052)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (50481178..50498991, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables choline kinase activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerophospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ethanolamine kinase 2

Names: ethanolamine kinase-like protein

NP_001406523.1

EC 2.7.1.82

XP_063128534.1

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419594.1 → NP_001406523.1 ethanolamine kinase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

D3ZRW8, D4A6J5

Related

ENSRNOP00000110024.1, ENSRNOT00000135110.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

47362964..47381100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272464.1 → XP_063128534.1 ethanolamine kinase 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108343.1: Suppressed sequence

Description

NM_001108343.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.