Dnai2 dynein, axonemal, intermediate chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnai2provided by RGD
Official Full Name: dynein, axonemal, intermediate chain 2provided by RGD
Primary source: RGD:1359602
See related: EnsemblRapid:ENSRNOG00000024523 AllianceGenome:RGD:1359602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnaic2
Summary: Predicted to enable dynein heavy chain binding activity; dynein light chain binding activity; and microtubule motor activity. Predicted to be involved in cilium movement; determination of left/right symmetry; and outer dynein arm assembly. Predicted to act upstream of or within cilium assembly. Predicted to be located in several cellular components, including dynein axonemal particle; external side of plasma membrane; and sperm flagellum. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 81.2) and Lung (RPKM 21.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (100259022..100292427)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (99759966..99793379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (103266343..103301521)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of outer dynein arm	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal intermediate chain 2

Names: axonemal dynein intermediate chain 2; dynein intermediate chain 2, axonemal; dynein, axonemal, intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007726.1 → NP_001007727.1 dynein axonemal intermediate chain 2

Status: PROVISIONAL

Source sequence(s)

BC081920

UniProtKB/Swiss-Prot

Q66HC9

UniProtKB/TrEMBL

A6HKI7

Related

ENSRNOP00000033498.3, ENSRNOT00000038852.6

Conserved Domains (3) summary

COG2319
Location:166 → 489

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 212

7WD40; WD40 repeat [structural motif]

cl02567
Location:166 → 472

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...