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    Pigu phosphatidylinositol glycan anchor biosynthesis, class U [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353304, updated on 2-Nov-2024

    Summary

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    Symbol
    Piguprovided by RGD
    Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Uprovided by RGD
    Primary source
    RGD:727825
    See related
    EnsemblRapid:ENSRNOG00000025181 AllianceGenome:RGD:727825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sakura; Cdc91l1; LRRGT00059
    Summary
    Predicted to contribute to GPI anchor binding activity. Predicted to be involved in GPI anchor biosynthetic process; attachment of GPI anchor to protein; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in plasma membrane. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 75.4), Lung (RPKM 61.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigu in Genome Data Viewer
    Location:
    3q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164245011..164341444, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143784831..143881268, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150803096..150885597, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene 40S ribosomal protein S12-like Neighboring gene RNA, U6 small nuclear 524 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene microRNA 6334 Neighboring gene nuclear receptor coactivator 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer. Guo Z, et al. Nat Med, 2004 Apr. PMID 15034568
    2. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Hong Y, et al. Mol Biol Cell, 2003 May. PMID 12802054, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GPI anchor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to GPI anchor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of GPI-anchor transamidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class U protein
    Names
    CDC91 cell division cycle 91-like 1
    GPI transamidase component PIG-U
    cell division cycle protein 91-like 1
    liver regeneration-related protein LRRGT00059
    protein CDC91-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181637.2 → NP_853668.1  phosphatidylinositol glycan anchor biosynthesis class U protein

      See identical proteins and their annotated locations for NP_853668.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8CHJ1
      UniProtKB/TrEMBL
      A6KI30, F1LPK9
      Related
      ENSRNOP00000032963.6, ENSRNOT00000034708.7
      Conserved Domains (1) summary
      pfam06728
      Location:20 → 394
      PIG-U; GPI transamidase subunit PIG-U

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164245011..164341444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105329.2 → XP_038961257.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAR3, F1LPK9
      Related
      ENSRNOP00000075495.2, ENSRNOT00000089935.3
      Conserved Domains (1) summary
      pfam06728
      Location:1 → 351
      PIG-U; GPI transamidase subunit PIG-U

    2. XM_039105330.2 → XP_038961258.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X2

      UniProtKB/TrEMBL
      A6KI31, F1LPK9
      Conserved Domains (1) summary
      pfam06728
      Location:1 → 310
      PIG-U; GPI transamidase subunit PIG-U

    3. XM_063284048.1 → XP_063140118.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X3

    4. XM_063284049.1 → XP_063140119.1  phosphatidylinositol glycan anchor biosynthesis class U protein isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHJ1.3 GenPept UniProtKB/Swiss-Prot:Q8CHJ1

    Gene LinkOut

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