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    IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) [ Homo sapiens (human) ]

    Gene ID: 3501, updated on 28-Oct-2024

    Summary

    Official Symbol
    IGHG2provided by HGNC
    Official Full Name
    immunoglobulin heavy constant gamma 2 (G2m marker)provided by HGNC
    Primary source
    HGNC:HGNC:5526
    See related
    Ensembl:ENSG00000211893 IMGT/GENE-DB:IGHG2; MIM:147110; AllianceGenome:HGNC:5526
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See IGHG2 in Genome Data Viewer
    Location:
    14q32.33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105643203..105644789, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99915504..99917090, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106109540..106111126, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 8071-2 Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 4 (G4m marker) Neighboring gene ETS transcription factor ELK2A, pseudogene Neighboring gene immunoglobulin heavy constant gamma P (non-functional) Neighboring gene immunoglobulin heavy constant alpha 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • Constant region of heavy chain of IgG2
    • immunoglobulin gamma 2 (Gm marker)
    • immunoglobulin heavy constant gamma 2 (Gm marker)

    Clone Names

    • DKFZp686I04196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001019.6 

      Range
      1235556..1237248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105643203..105644789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      110972..112558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99915504..99917090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)