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    Dlg5 Discs large 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34573, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dlg5provided by FlyBase
    Official Full Name
    Discs large 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0032363
    Locus tag
    Dmel_CG6509
    See related
    AllianceGenome:FB:FBgn0032363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6509; Dlg; dlg5; DLG5; Dmel\CG6509; LD32687
    Summary
    Involved in border follicle cell migration and negative regulation of hippo signaling. Located in apical part of cell. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Dlg5 in Genome Data Viewer
    Location:
    32F2-32F2; 2-44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11508399..11517081, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11508399..11517081, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spalt-adjacent Neighboring gene Component of oligomeric golgi complex 8 Neighboring gene spatzle 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization. Reilly E, et al. G3 (Bethesda), 2015 Mar 19. PMID 25795662, Free PMC Article
    2. Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster. Venugopal P, et al. BMC Dev Biol, 2020 Jun 18. PMID 32552730, Free PMC Article
    3. A modular toolset of phiC31-based fluorescent protein tagging vectors for Drosophila. Luo J, et al. Fly (Austin), 2019 Mar-Dec. PMID 30885036, Free PMC Article
    4. The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes. Mysh M, et al. J Am Soc Nephrol, 2021 Jun 1. PMID 33795424, Free PMC Article
    5. The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis. Luo J, et al. PLoS One, 2019. PMID 31856229, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    discs large 5
    Names
    CG6509-PA
    CG6509-PB
    CG6509-PC
    CG6509-PD
    Dlg5-PA
    Dlg5-PB
    Dlg5-PC
    Dlg5-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11508399..11517081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164967.2 → NP_723672.1  discs large 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKG8
      Related
      FBpp0079832
      Conserved Domains (7) summary
      cd11860
      Location:1594 → 1657
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      cd00992
      Location:1497 → 1576
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:1737 → 1904
      Guanylate_kin; Guanylate kinase
      pfam06476
      Location:326 → 408
      DUF1090; Protein of unknown function (DUF1090)
      pfam10473
      Location:229 → 360
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13476
      Location:165 → 333
      AAA_23; AAA domain
      cl17190
      Location:1773 → 1905
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001273455.1 → NP_001260384.1  discs large 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCQ6
      Conserved Domains (4) summary
      cd00992
      Location:1290 → 1369
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam06476
      Location:326 → 408
      DUF1090; Protein of unknown function (DUF1090)
      pfam10473
      Location:229 → 360
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13476
      Location:165 → 333
      AAA_23; AAA domain

    3. NM_001273456.1 → NP_001260385.1  discs large 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD90
      Conserved Domains (7) summary
      cd11860
      Location:1593 → 1656
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      cd00992
      Location:1496 → 1575
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:1736 → 1903
      Guanylate_kin; Guanylate kinase
      pfam06476
      Location:325 → 407
      DUF1090; Protein of unknown function (DUF1090)
      pfam10473
      Location:228 → 359
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13476
      Location:164 → 332
      AAA_23; AAA domain
      cl17190
      Location:1772 → 1904
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. NM_135661.3 → NP_609505.1  discs large 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKG8
      Related
      FBpp0079831
      Conserved Domains (7) summary
      cd11860
      Location:1594 → 1657
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      cd00992
      Location:1497 → 1576
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:1737 → 1904
      Guanylate_kin; Guanylate kinase
      pfam06476
      Location:326 → 408
      DUF1090; Protein of unknown function (DUF1090)
      pfam10473
      Location:229 → 360
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13476
      Location:165 → 333
      AAA_23; AAA domain
      cl17190
      Location:1773 → 1905
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCQ6 M9PCQ6
    M9PD90 M9PD90
    Q9VKG8 Q9VKG8

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