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    Nrep neuronal regeneration related protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 338475, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nrepprovided by RGD
    Official Full Name
    neuronal regeneration related proteinprovided by RGD
    Primary source
    RGD:631411
    See related
    EnsemblRapid:ENSRNOG00000068914 AllianceGenome:RGD:631411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P311
    Summary
    Involved in axon regeneration and regulation of neuron differentiation. Predicted to be located in cytoplasm. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 596.9), Brain (RPKM 471.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrep in Genome Data Viewer
    Location:
    18p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (25291219..25320742, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25017069..25046593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (26183753..26212796, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene uncharacterized LOC134482925 Neighboring gene StAR-related lipid transfer domain containing 4 Neighboring gene uncharacterized LOC102549443 Neighboring gene uncharacterized LOC120098267 Neighboring gene uncharacterized LOC120098268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells. Jiang J, et al. Mol Cell Biochem, 2023 Feb. PMID 35779227
    2. Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats. Qi FH, et al. Int J Mol Med, 2018 May. PMID 29436600
    3. Adenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway. Qi F, et al. Biosci Trends, 2015 Oct. PMID 26559022
    4. Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells. Zhang Y, et al. Ren Fail, 2015. PMID 26335191
    5. P311 accelerates nerve regeneration of the axotomized facial nerve. Fujitani M, et al. J Neurochem, 2004 Nov. PMID 15485502

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
      Title: P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells.
    2. P311 may be involved in the pathogenesis of renal fibrosis by blocking TGF-beta1-mediated epithelial-mesenchymal transition via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion kidneys.
      Title: Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats.
    3. efficiently blocked Smad-ILK pathway activation and attenuated epithelial-mesenchymal transition induced by TGF-beta1
      Title: Adenovirus-mediated P311 inhibits TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells via TGF-β1-Smad-ILK pathway.
    4. P311 gene, together with alpha-SMA and TGF-beta1 genes, was induced in the process of Tubular epithelial-myofibroblast transition (TEMT) in rat.
      Title: Role of P311 in interleukin-1α-induced epithelial to myofibroblast transition in kidney tubular epithelial cells.
    5. identified a gene, previously designated P311, up-regulated in axotomized facial motoneurons; ectopically expressed P311 localizes in the cytoplasm and the nucleus; over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells to differentiate [P311]
      Title: P311 accelerates nerve regeneration of the axotomized facial nerve.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal regeneration-related protein
    Names
    neuronal protein 3.1
    protein p311

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419560.1 → NP_001406489.1  neuronal regeneration-related protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q80Z34
      UniProtKB/TrEMBL
      A6J2S2
      Related
      ENSRNOP00000086813.1, ENSRNOT00000119499.2

    2. NM_001419561.1 → NP_001406490.1  neuronal regeneration-related protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q80Z34
      UniProtKB/TrEMBL
      A6J2S2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      25291219..25320742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277456.1 → XP_063133526.1  neuronal regeneration-related protein isoform X1

      UniProtKB/Swiss-Prot
      Q80Z34
      UniProtKB/TrEMBL
      A6J2S2

    2. XM_063277457.1 → XP_063133527.1  neuronal regeneration-related protein isoform X1

      UniProtKB/Swiss-Prot
      Q80Z34
      UniProtKB/TrEMBL
      A6J2S2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Z34.1 GenPept UniProtKB/Swiss-Prot:Q80Z34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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