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    CD163L1 CD163 molecule-like 1 [ Bos taurus (cattle) ]

    Gene ID: 338056, updated on 16-Jan-2024

    Summary

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    Gene symbol
    CD163L1
    Gene description
    CD163 molecule-like 1
    See related
    BGD:BT11615; Ensembl:ENSBTAG00000054245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    WC1; WC1-2; WC1-5; WC1.1
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    Genomic context

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    See CD163L1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (103022467..103086236, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345381 Neighboring gene antigen WC1.1-like Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like Neighboring gene antigen WC1.1-like Neighboring gene transmembrane emp24 domain-containing protein 7-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyrosine phosphorylation of scavenger receptor cysteine-rich WC1 is required for the WC1-mediated potentiation of TCR-induced T-cell proliferation. Wang F, et al. Eur J Immunol, 2009 Jan. PMID 19130552
    2. Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes. Wijngaard PL, et al. J Immunol, 1992 Nov 15. PMID 1431105
    3. Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes. Wijngaard PL, et al. J Immunol, 1994 Apr 1. PMID 7511649
    4. Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes. Chen C, et al. BMC Genet, 2012 Oct 16. PMID 23072335, Free PMC Article
    5. Gammadelta T cell function varies with the expressed WC1 coreceptor. Rogers AN, et al. J Immunol, 2005 Mar 15. PMID 15749871

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of the second tyrosine in the WC1 cytoplasmic domain was required for the WC1-mediated potentiation of TCR-induced T-cell proliferation, suggesting that WC1 acts as a co-stimulatory molecule for gammadelta TCR
      Title: Tyrosine phosphorylation of scavenger receptor cysteine-rich WC1 is required for the WC1-mediated potentiation of TCR-induced T-cell proliferation.
    2. While the major gamma delta T cell subpopulations in blood (WC1.1+/WC1.2- and WC1.2+/WC1.1-) both have complex western blot patterns, virtually all spots associated with WC1.2+/WC1.1- cells bear the WC1.2 epitope, distinguishing them from WC1.1+ cells.
      Title: Characterization of WC1 co-receptors on functionally distinct subpopulations of ruminant gamma delta T cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antigen WC1.1
    Names
    WC1 tail
    WC1-5 transmembrane protein
    WC1.1 molecule
    WC1.1 tail

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176651.1 → NP_788824.1  antigen WC1.1 precursor

      See identical proteins and their annotated locations for NP_788824.1

      Status: PROVISIONAL

      Source sequence(s)
      X63723
      UniProtKB/Swiss-Prot
      P30205
      UniProtKB/TrEMBL
      B6ULX3
      Related
      ENSBTAP00000074579.1, ENSBTAT00000066369.2
      Conserved Domains (2) summary
      smart00202
      Location:376 → 476
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:381 → 476
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      103022467..103086236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30205.1 GenPept UniProtKB/Swiss-Prot:P30205

    Gene LinkOut

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