CYP11A1 cytochrome P450 family 11 subfamily A member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CYP11A1provided by VGNC
Official Full Name: cytochrome P450 family 11 subfamily A member 1provided by VGNC
Primary source: VGNC:VGNC:110229
See related: BGD:BT16538; Ensembl:ENSBTAG00000006934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CYP11A; CYPXIA1; P450scc; P450(scc)
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (34328585..34342887)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

isoleucine residues 351 and 461, and leucine residue 355 are important for the cytochrome P450scc functioning towards sterols both with unbranched (cholesterol) and branched (sitosterol) side chains
Title: Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1).
We constructed cDNA including genes of the bovine cholesterol hydroxylase/lyase (CHL) system proteins-cytochrome P450scc (CYP11A1), adrenodoxin (Adx) and adrenodoxin reductase (AdR), that are fused into a single ORF using FMDV 2A nucleotide sequences.
Title: Expression of Cholesterol Hydroxylase/Lyase System Proteins in Yeast S. cerevisiae Cells as a Self-Processing Polyprotein.
Data indicate a role of cytochrome P450 11A1 (CYP11A1 in sterol metabolism.
Title: Lumisterol is metabolized by CYP11A1: discovery of a new pathway.
Bovine CYP11A1 manifests 2beta- and 16beta-hydroxylase activity.
Title: 2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation.
Data suggest that the upstream region of gene encoding CYP11A contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex.
Title: Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Title: Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).
Title: Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).
Focimatrix may potentially regulate CYP11A1 expression, and the regulation of both could be important in ovarian follicular dominance.
Title: Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1.
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
Title: Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
Data show that a deletion of 20 amino acids comprising parts of the F-G loop results in an enzyme with a three-fold increased solubility, the highest solubility of a CYP11A1 variant obtained so far.
Title: Substitution of lysine with glutamic acid at position 193 in bovine CYP11A1 significantly affects protein oligomerization and solubility but not enzymatic activity.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cortisol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cholesterol side-chain cleavage enzyme, mitochondrial

Names: cholesterol desmolase; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450, family 11, subfamily A, polypeptide 1

NP_788817.1

EC 1.14.15.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.