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    Fndc3c1 fibronectin type III domain containing 3C1 [ Mus musculus (house mouse) ]

    Gene ID: 333564, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fndc3c1provided by MGI
    Official Full Name
    fibronectin type III domain containing 3C1provided by MGI
    Primary source
    MGI:MGI:2685630
    See related
    Ensembl:ENSMUSG00000033737 AllianceGenome:MGI:2685630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm784; Fndc3c
    Summary
    Predicted to be involved in spermatid development. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in embryo; embryo endoderm; and extraembryonic ectoderm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 9.0), limb E14.5 (RPKM 4.7) and 2 other tissues See more
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    Genomic context

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    See Fndc3c1 in Genome Data Viewer
    Location:
    X D; X 47.36 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105463647..105529436, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106420041..106485577, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 6382 Neighboring gene fibronectin type III domain containing 3C1 pseudogene Neighboring gene cysteinyl leukotriene receptor 1 Neighboring gene STARR-seq mESC enhancer starr_47737 Neighboring gene predicted gene, 24622 Neighboring gene predicted gene 5127 Neighboring gene predicted gene 14877

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FNDC3A is required for adhesion between spermatids and Sertoli cells. Obholz KL, et al. Dev Biol, 2006 Oct 15. PMID 16904100, Free PMC Article
    2. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Pearton DJ, et al. Dev Biol, 2014 Aug 15. PMID 24859262
    3. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
    4. Transcriptional analysis of cleft palate in TGFβ3 mutant mice. Liu J, et al. Sci Rep, 2020 Sep 10. PMID 32913205, Free PMC Article
    5. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, et al. Genes Dev, 2012 Oct 15. PMID 23070814, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100196, MGC100347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain containing protein 3C1
    Names
    fibronectin domain-containing protein 3c
    fibronectin type III domain containing protein 3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007580.1 → NP_001007581.1  fibronectin type III domain containing protein 3C1

      Status: PROVISIONAL

      Source sequence(s)
      BC076625
      Consensus CDS
      CCDS30342.1
      UniProtKB/Swiss-Prot
      Q6DFV6
      Related
      ENSMUSP00000038678.8, ENSMUST00000039447.14
      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:1026 → 1100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105463647..105529436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247621.2 → XP_011245923.1  fibronectin type III domain containing protein 3C1 isoform X3

      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:988 → 1062
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    2. XM_006528103.3 → XP_006528166.1  fibronectin type III domain containing protein 3C1 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFV6
      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:1026 → 1100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    3. XM_006528104.5 → XP_006528167.1  fibronectin type III domain containing protein 3C1 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFV6
      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:1026 → 1100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    4. XM_006528106.4 → XP_006528169.1  fibronectin type III domain containing protein 3C1 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFV6
      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:1026 → 1100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    5. XM_011247620.3 → XP_011245922.1  fibronectin type III domain containing protein 3C1 isoform X2

      Conserved Domains (3) summary
      PRK08581
      Location:235 → 473
      PRK08581; amidase domain-containing protein
      cd00063
      Location:990 → 1064
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:424 → 510
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

    6. XM_017318527.2 → XP_017174016.1  fibronectin type III domain containing protein 3C1 isoform X1

      UniProtKB/Swiss-Prot
      Q6DFV6
      Conserved Domains (3) summary
      PRK08581
      Location:271 → 509
      PRK08581; amidase domain-containing protein
      cd00063
      Location:1026 → 1100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16656
      Location:460 → 546
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFV6.1 GenPept UniProtKB/Swiss-Prot:Q6DFV6

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