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    Zfp36l3 zinc finger protein 36, C3H type-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 333473, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp36l3provided by MGI
    Official Full Name
    zinc finger protein 36, C3H type-like 3provided by MGI
    Primary source
    MGI:MGI:3525151
    See related
    Ensembl:ENSMUSG00000059334 AllianceGenome:MGI:3525151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Is expressed in extraembryonic component; forebrain; olfactory epithelium; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 29.0) See more
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    Genomic context

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    See Zfp36l3 in Genome Data Viewer
    Location:
    X A5; X 30.06 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52774653..52778361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53772686..53776394, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700013H16 gene Neighboring gene predicted pseudogene 6025 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene X-linked lymphocyte-regulated Neighboring gene X-linked lymphocyte-regulated complex pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3. Frederick ED, et al. J Biol Chem, 2008 May 23. PMID 18367448, Free PMC Article
    2. Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Stumpo DJ, et al. Development, 2016 Apr 15. PMID 26952984, Free PMC Article
    3. Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Blackshear PJ, et al. Biol Reprod, 2005 Aug. PMID 15814898
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice deficient in ZFP36L3 exhibited decreased neonatal survival rates, but no apparent morphological changes in the placenta or surviving offspring.
      Title: Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.
    2. ZFP36L3 is a "full-time" cytosolic protein, rather than a nucleocytoplasmic shuttling protein
      Title: A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA decay activator protein ZFP36L3
    Names
    zinc finger protein 36, C3H1 type-like 3
    zinc finger protein 36-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009549.2 → NP_001009549.1  mRNA decay activator protein ZFP36L3

      Status: VALIDATED

      Source sequence(s)
      AV223369, AY661338, BY393504
      Consensus CDS
      CCDS30138.1
      UniProtKB/Swiss-Prot
      Q5ISE2
      Related
      ENSMUSP00000071630.4, ENSMUST00000071711.4
      Conserved Domains (1) summary
      COG5063
      Location:31 → 185
      CTH1; CCCH-type Zn-finger protein [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52774653..52778361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ISE2.1 GenPept UniProtKB/Swiss-Prot:Q5ISE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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