Bx Beadex [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bxprovided by FlyBase
Official Full Name: Beadexprovided by FlyBase
Primary source: FLYBASE:FBgn0265598
Locus tag: Dmel_CG44425
See related: AllianceGenome:FB:FBgn0265598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bd; beadex/dLMO; bx; CG10548; CG15048; CG44425; CG6500; dlmo; dLmo; dLMO; Dlmo; DLMO; dLmo (Bx); dLMO(Beadex); Dmel\CG44425; dttg; fliH; hdp; hdp-a; hld; Lmo; LMO; Ptd; Rho
Old locus tag: Dmel_CG15048; Dmel_CG6500
Summary: Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including gastric emptying; imaginal disc-derived appendage morphogenesis; and locomotor rhythm. Predicted to be active in nucleus. Is expressed in several structures, including adult pacemaker neurons; brain; cuboidal/columnar epithelium; glial cell; and imaginal disc. Orthologous to human LMO1 (LIM domain only 1) and LMO3 (LIM domain only 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 17C1-17C4; 1-60 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18515428..18572809)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18409461..18466842)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction.
Title: Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction.
Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development in Drosophila melanogaster.
Title: Beadex, a homologue of the vertebrate LIM domain only protein, is a novel regulator of crystal cell development in Drosophila melanogaster.
Knock-down of Beadex, a Drosophila LIM domain only protein, in follicle cells leads to abnormal eggs, reduced fecundity and fertility in Drosophila.
Title: Beadex, a Drosophila LIM domain only protein, function in follicle cells is essential for egg development and fertility.
The function of Chi and dLMO on Notch signaling is dependent on the regulation of fng transcription.
Title: Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
The Beadex mutant showed highly compromised reproductive abilities as evaluated by reduced fecundity and fertility, abnormal oviposition and more importantly, the failure of sperm release from storage organs.
Title: Beadex function in the motor neurons is essential for female reproduction in Drosophila melanogaster.
Beadex impacts gastric emptying in Drosophila. Adult A523 mutant displayed a bloated abdomen.
Title: Beadex affects gastric emptying in Drosophila.
study found that reduced Lmo activity increased sensitivity to ethanol-induced sedation, whereas increased expression of Lmo led to increased resistance to ethanol-induced sedation
Title: Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.
dLMO, in addition to senseless, contributes to the bristle defects of the mir-9a mutant.
Title: miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only.
These data indicate that a function of mir-9a is to ensure the appropriate stoichiometry of dLMO during Drosophila wing development.
Title: Drosophila mir-9a regulates wing development via fine-tuning expression of the LIM only factor, dLMO.
a novel role of DLMO (Drosophila LIM-only) as a positive regulator of transcription during the development of thoracic sensory bristles.
Title: Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 18555434-18556897 mobile_element_type = transposon:transib2{}157

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric emptying	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of branching morphogenesis of a nerve	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: beadex

Names: Bx-PA; Bx-PB; Bx-PC; Bx-PD; Bx-PF; CG44425-PA; CG44425-PB; CG44425-PC; CG44425-PD; CG44425-PF; LIM-only; flightless-H; held-up; heldup a; pointedoid; rhombotin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18515428..18572809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272759.2 → NP_001259688.2 beadex, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259688.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PHX4

Conserved Domains (2) summary

cd09388
Location:162 → 216

LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

cd09390
Location:226 → 280

LIM2_dLMO; The second LIM domain of dLMO (Beaderx)
NM_176758.3 → NP_788931.1 beadex, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788931.1

Status: REVIEWED

UniProtKB/TrEMBL

O77284

Related

FBpp0309324

Conserved Domains (2) summary

cd09388
Location:92 → 146

LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

cd09390
Location:156 → 210

LIM2_dLMO; The second LIM domain of dLMO (Beaderx)
NM_167625.3 → NP_728184.1 beadex, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728184.1

Status: REVIEWED

UniProtKB/TrEMBL

O77284

Related

FBpp0309322

Conserved Domains (2) summary

cd09388
Location:92 → 146

LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

cd09390
Location:156 → 210

LIM2_dLMO; The second LIM domain of dLMO (Beaderx)
NM_001272758.1 → NP_001259687.1 beadex, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259687.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI02

Conserved Domains (2) summary

cd09388
Location:92 → 146

LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

cd09390
Location:156 → 210

LIM2_dLMO; The second LIM domain of dLMO (Beaderx)
NM_078678.4 → NP_523402.4 beadex, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523402.4

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQX7

Related

FBpp0309323

Conserved Domains (2) summary

cd09388
Location:163 → 217

LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

cd09390
Location:227 → 281

LIM2_dLMO; The second LIM domain of dLMO (Beaderx)