pcnt pericentrin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcntprovided by ZNC
Official Full Name: pericentrinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030829-26
See related: Ensembl:ENSDARG00000033012 AllianceGenome:ZFIN:ZDB-GENE-030829-26
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc85c01; sb:cb754; wu:fc85c01; si:ch211-245b3.1
Summary: Predicted to enable DNA binding activity and molecular adaptor activity. Predicted to be involved in microtubule nucleation and mitotic spindle organization. Predicted to act upstream of or within signal transduction. Predicted to be located in centrosome and cytoplasm. Is expressed in several structures, including digestive system; heart tube; nervous system; pectoral fin musculature; and pronephric duct. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (11272272..11362923, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (11036845..11127478, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pericentrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346290.1 → NP_001333219.1 pericentrin

Status: VALIDATED

Source sequence(s)

BX936453, CT963095

UniProtKB/TrEMBL

A0A8M1P4C4, I3ISP1

Related

ENSDARP00000125930.1, ENSDART00000151125.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

11272272..11362923 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002662304.7 → XP_002662350.3 pericentrin isoform X3

UniProtKB/TrEMBL

A0A8M1RDI9

Conserved Domains (7) summary

pfam05483
Location:2268 → 3005

SCP-1; Synaptonemal complex protein 1 (SCP-1)

COG1196
Location:764 → 1605

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1276 → 2105

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl22980
Location:240 → 399

Csx12; CRISPR/Cas system-associated protein Cas9

pfam10495
Location:4045 → 4122

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl19219
Location:2832 → 2945

DUF342; Protein of unknown function (DUF342)

cl23887
Location:1201 → 1317

DUF4349; Domain of unknown function (DUF4349)
XM_021476785.2 → XP_021332460.1 pericentrin isoform X2

UniProtKB/TrEMBL

A0A8M9QF75

Conserved Domains (3) summary

pfam10495
Location:4047 → 4124

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl25732
Location:2289 → 3128

SMC_N; RecF/RecN/SMC N terminal domain

cl26511
Location:3417 → 4063

Neuromodulin_N; Gap junction protein N-terminal region
XM_021476784.2 → XP_021332459.1 pericentrin isoform X1

UniProtKB/TrEMBL

A0A8M9Q5Z1

Conserved Domains (3) summary

pfam10495
Location:4054 → 4131

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

cl25732
Location:2344 → 3135

SMC_N; RecF/RecN/SMC N terminal domain

cl26511
Location:3424 → 4070

Neuromodulin_N; Gap junction protein N-terminal region