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    waca WW domain containing adaptor with coiled-coil a [ Danio rerio (zebrafish) ]

    Gene ID: 323904, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wacaprovided by ZNC
    Official Full Name
    WW domain containing adaptor with coiled-coil aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2624
    See related
    Ensembl:ENSDARG00000012577 AllianceGenome:ZFIN:ZDB-GENE-030131-2624
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wac; zgc:55755; wu:fc13f04; wu:fj68f01
    Summary
    Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; positive regulation of DNA-templated transcription; and positive regulation of TORC1 signaling. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in DeSanto-Shinawi syndrome. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See waca in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23356500..23416290)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23235281..23295071)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox a Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene MAGUK p55 scaffold protein 7a Neighboring gene uncharacterized LOC103911922 Neighboring gene BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-containing adapter protein with coiled-coil
    Names
    WW domain-containing adapter with a coiled-coil region

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199660.1 → NP_955954.1  WW domain-containing adapter protein with coiled-coil

      See identical proteins and their annotated locations for NP_955954.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048888
      UniProtKB/Swiss-Prot
      Q6PUS1, Q7ZUK7
      Conserved Domains (1) summary
      pfam00397
      Location:124 → 151
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      23356500..23416290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306588.3 → XP_009304863.1  WW domain-containing adapter protein with coiled-coil isoform X1

      UniProtKB/TrEMBL
      A0A8M3AY70, F1QS79
      Related
      ENSDARP00000073355.3, ENSDART00000078896.6
      Conserved Domains (1) summary
      pfam00397
      Location:124 → 151
      WW; WW domain

    2. XM_005156197.3 → XP_005156254.1  WW domain-containing adapter protein with coiled-coil isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2I3
      Conserved Domains (1) summary
      pfam00397
      Location:124 → 151
      WW; WW domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUK7.1 GenPept UniProtKB/Swiss-Prot:Q7ZUK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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