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    Sycp2 synaptonemal complex protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 320558, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sycp2provided by MGI
    Official Full Name
    synaptonemal complex protein 2provided by MGI
    Primary source
    MGI:MGI:1933281
    See related
    Ensembl:ENSMUSG00000060445 AllianceGenome:MGI:1933281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830402K23Rik; 4930518F03Rik
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within several processes, including male genitalia morphogenesis; meiotic nuclear division; and negative regulation of apoptotic process. Located in lateral element. Is expressed in meiotic germ cell of ovary; oocyte; primary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 1. Orthologous to human SYCP2 (synaptonemal complex protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 6.1) and CNS E18 (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Sycp2 in Genome Data Viewer
    Location:
    2 H4; 2 99.81 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177987088..178051580, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178345295..178407776, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06699 Neighboring gene zinc finger protein 931 Neighboring gene phosphatase and actin regulator 3 Neighboring gene GC-rich promoter binding protein 1 pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B Neighboring gene predicted gene, 35532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells. Pelttari J, et al. Mol Cell Biol, 2001 Aug. PMID 11463847, Free PMC Article
    2. Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex. Feng J, et al. Protein Cell, 2017 Jul. PMID 28150150, Free PMC Article
    3. Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment. Kolas NK, et al. Cytogenet Genome Res, 2004. PMID 15237206
    4. The RNA-binding specificity of the mouse Dazl protein. Venables JP, et al. Nucleic Acids Res, 2001 Jun 15. PMID 11410654, Free PMC Article
    5. Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. Yang F, et al. J Cell Biol, 2006 May 22. PMID 16717126, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using yeast two-hybrid screening, it discovered the surprising finding that the SYCP2 NTR associates well with the centromere. It was reported that the C-terminal region of mSYCP2 was found to be responsible for the association of SYCP3 and SYCP1 for synaptonemal complex (SC) formation.
      Title: Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex.
    2. SYCP2 are not required for centromere cohesion at the metaphase-I stage in male germ cells.
      Title: SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division.
    3. SYCP2 is a primary determinant of axial elements and lateral elements and, thus, is required for the incorporation of SYCP3 into synaptonemal complexes.
      Title: Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.
    4. SYCP2 and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core
      Title: Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment.
    5. SYCP2 is a primary determinant of axial/lateral elements (AEs/LEs) and is required for the incorporation of SYCP3 into synaptonemal complexes.
      Title: Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic G1 phase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lateral element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptonemal complex protein 2
    Names
    SCP-2
    synaptonemal complex lateral element protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177191.3 → NP_796165.2  synaptonemal complex protein 2

      See identical proteins and their annotated locations for NP_796165.2

      Status: VALIDATED

      Source sequence(s)
      AL772217, DQ103262
      Consensus CDS
      CCDS38370.1
      UniProtKB/Swiss-Prot
      A2AJW2, Q1G7B6, Q9CUU3
      Related
      ENSMUSP00000079909.4, ENSMUST00000081134.10
      Conserved Domains (1) summary
      COG4399
      Location:43 → 236
      YheB; Uncharacterized membrane protein YheB, UPF0754 family [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      177987088..178051580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500664.4 → XP_006500727.1  synaptonemal complex protein 2 isoform X2

      Conserved Domains (1) summary
      pfam18584
      Location:53 → 164
      SYCP2_SLD; Synaptonemal complex 2 Spt16M-like domain

    2. XM_017319020.3 → XP_017174509.1  synaptonemal complex protein 2 isoform X1

      Conserved Domains (2) summary
      pfam18581
      Location:1 → 85
      SYCP2_ARLD; Synaptonemal complex 2 armadillo-repeat-like domain
      pfam18584
      Location:179 → 290
      SYCP2_SLD; Synaptonemal complex 2 Spt16M-like domain

    RNA

    1. XR_003953467.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CUU3.2 GenPept UniProtKB/Swiss-Prot:Q9CUU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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