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    Lmbrd2 LMBR1 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 320506, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lmbrd2provided by MGI
    Official Full Name
    LMBR1 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2444173
    See related
    Ensembl:ENSMUSG00000039704 AllianceGenome:MGI:2444173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9930036E21Rik
    Summary
    Predicted to be involved in adrenergic receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in Meckel's cartilage; cranial ganglion; hindlimb long bone; and tarsus. Orthologous to human LMBRD2 (LMBR1 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 5.7), genital fat pad adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmbrd2 in Genome Data Viewer
    Location:
    15 A1; 15 3.86 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9140622..9202564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9140528..9202483)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene S-phase kinase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor-associated protein LMBRD2
    Names
    LMBR1 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418870.1 → NP_001405799.1  G-protein coupled receptor-associated protein LMBRD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139209
      UniProtKB/Swiss-Prot
      Q3U5C1, Q501M6, Q8BQ06, Q8C561

    2. NM_001418874.1 → NP_001405803.1  G-protein coupled receptor-associated protein LMBRD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139209
      Related
      ENSMUSP00000087858.6, ENSMUST00000090380.6

    3. NM_001418875.1 → NP_001405804.1  G-protein coupled receptor-associated protein LMBRD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139209

    4. NM_177178.4 → NP_796152.2  G-protein coupled receptor-associated protein LMBRD2 isoform 1

      See identical proteins and their annotated locations for NP_796152.2

      Status: VALIDATED

      Source sequence(s)
      AC139209
      Consensus CDS
      CCDS37039.1
      UniProtKB/Swiss-Prot
      Q3U5C1, Q501M6, Q8BQ06, Q8C561
      Related
      ENSMUSP00000154020.2, ENSMUST00000227556.3
      Conserved Domains (1) summary
      pfam04791
      Location:1 → 549
      LMBR1; LMBR1-like membrane protein

    RNA

    1. NR_184843.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139209

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      9140622..9202564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520092.5 → XP_006520155.1  G-protein coupled receptor-associated protein LMBRD2 isoform X2

      Conserved Domains (1) summary
      pfam04791
      Location:1 → 421
      LMBR1; LMBR1-like membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C561.1 GenPept UniProtKB/Swiss-Prot:Q8C561

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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