Ppm1e protein phosphatase 1E (PP2C domain containing) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1eprovided by MGI
Official Full Name: protein phosphatase 1E (PP2C domain containing)provided by MGI
Primary source: MGI:MGI:2444096
See related: Ensembl:ENSMUSG00000046442 AllianceGenome:MGI:2444096
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: POPX1; PP2CH; mKIAA1072; B930008A12Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; bone; central nervous system; retina; and spleen. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 37.0), CNS E18 (RPKM 18.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87117724..87249884, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87226906..87358994, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ksks326 (e-PCR)
- UniSTS:514371

AW049266 (e-PCR)
- UniSTS:164474

D11Fpm104 (e-PCR)
- UniSTS:510461

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1E

Names: ca(2+)/calmodulin-dependent protein kinase phosphatase N; caMKN; caMKP-N; caMKP-nucleus; partner of PIX 1; partner of PIX-alpha; partner of PIXA

NP_796141.2

EC 3.1.3.16

XP_036012659.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177167.4 → NP_796141.2 protein phosphatase 1E

See identical proteins and their annotated locations for NP_796141.2

Status: VALIDATED

Source sequence(s)

AL596130

Consensus CDS

CCDS25211.1

UniProtKB/Swiss-Prot

Q5SX30, Q80TL0, Q8BGM6, Q8CB81

UniProtKB/TrEMBL

B2KGP3

Related

ENSMUSP00000061278.5, ENSMUST00000055438.5

Conserved Domains (1) summary

cd00143
Location:227 → 485

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87117724..87249884 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156766.1 → XP_036012659.1 protein phosphatase 1E isoform X1

Conserved Domains (1) summary

cd00143
Location:233 → 422

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...