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    dtr defective transmitter release [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318856, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dtrprovided by FlyBase
    Official Full Name
    defective transmitter releaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023090
    Locus tag
    Dmel_CG31623
    See related
    AllianceGenome:FB:FBgn0023090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31623; Dmel\CG31623; Dtr
    Summary
    Predicted to enable dynein complex binding activity. Involved in chemical synaptic transmission. Predicted to be located in axoneme. Is expressed in adult head; chordotonal neurons; and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See dtr in Genome Data Viewer
    Location:
    39D1-39D2; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21361216..21367288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21361216..21367288)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene dimmed Neighboring gene Tetraspanin 39D Neighboring gene Gustatory receptor 39b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA). Gengs C, et al. J Biol Chem, 2002 Nov 1. PMID 12196539
    2. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Stobdan T, et al. Mol Biol Evol, 2017 Dec 1. PMID 29029226, Free PMC Article
    3. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
    4. Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes. Banho CA, et al. Sci Rep, 2021 May 10. PMID 33972659, Free PMC Article
    5. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    defective transmitter release
    Names
    CG31623-PA
    dtr-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21361216..21367288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165375.3 → NP_724335.2  defective transmitter release [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724335.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6YNS3, Q8INT5
      Conserved Domains (4) summary
      cd00116
      Location:58 → 184
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:38 → 57
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:56 → 98
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:100 → 161
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INT5.2 Q8INT5

    Gene LinkOut

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