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    Txndc2 thioredoxin domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316777, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Txndc2provided by RGD
    Official Full Name
    thioredoxin domain containing 2provided by RGD
    Primary source
    RGD:1359251
    See related
    AllianceGenome:RGD:1359251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein disulfide isomerase activity and thioredoxin-disulfide reductase activity. Predicted to be involved in cell differentiation; cellular oxidant detoxification; and spermatogenesis. Predicted to act upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in outer dense fiber. Orthologous to human TXNDC2 (thioredoxin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 103.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Txndc2 in Genome Data Viewer
    Location:
    9q37
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (112677459..112682027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (105230575..105235131, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (113354047..113358558, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480621 Neighboring gene VAMP associated protein A Neighboring gene RAB31, member RAS oncogene family Neighboring gene uncharacterized LOC102552808

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation. Yu Y, et al. Biol Reprod, 2002 Nov. PMID 12390887
    2. Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein. Jiménez A, et al. Mol Hum Reprod, 2002 Aug. PMID 12149401
    3. Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa. Miranda-Vizuete A, et al. J Biol Chem, 2001 Aug 24. PMID 11399755
    4. Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Smith TB, et al. Free Radic Biol Med, 2013 Dec. PMID 23707457
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94320

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in outer dense fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 2
    Names
    spermatid-specific thioredoxin-1
    sptrx-1
    thioredoxin domain containing 2 (spermatozoa)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005559.2 → NP_001005559.2  thioredoxin domain-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC079238, CK597423
      UniProtKB/TrEMBL
      F1LV53
      Conserved Domains (1) summary
      cd02947
      Location:420 → 513
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    2. NM_001146004.1 → NP_001139476.1  thioredoxin domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001139476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC079238
      UniProtKB/Swiss-Prot
      Q5XHX6, Q6AY11
      Conserved Domains (2) summary
      PTZ00121
      Location:151 → 466
      PTZ00121; MAEBL; Provisional
      cd02947
      Location:454 → 547
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      112677459..112682027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245607.5 → XP_006245669.1  thioredoxin domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5XHX6
      Conserved Domains (1) summary
      cd02947
      Location:432 → 525
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    2. XM_039083806.2 → XP_038939734.1  thioredoxin domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JRC0
      Conserved Domains (2) summary
      PTZ00121
      Location:89 → 404
      PTZ00121; MAEBL; Provisional
      cd02947
      Location:392 → 485
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHX6.2 GenPept UniProtKB/Swiss-Prot:Q5XHX6

    Gene LinkOut

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