Prss35 serine protease 35 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss35provided by RGD
Official Full Name: serine protease 35provided by RGD
Primary source: RGD:1311282
See related: EnsemblRapid:ENSRNOG00000025184 AllianceGenome:RGD:1311282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS35 (serine protease 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 43.9), Testes (RPKM 27.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (96594460..96610992)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (87714449..87731009)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (94423629..94440509)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139901 (e-PCR)
- UniSTS:221985

AA866443 (e-PCR)
- UniSTS:226201

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive serine protease 35

Names: protease, serine, 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008560.2 → NP_001008560.2 inactive serine protease 35 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5R212

UniProtKB/TrEMBL

A6I1V5, F1LLW4

Related

ENSRNOP00000101798.1, ENSRNOT00000127674.1

Conserved Domains (1) summary

cl21584
Location:138 → 174

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

96594460..96610992

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595670.3 → XP_017451159.1 inactive serine protease 35 isoform X1

UniProtKB/Swiss-Prot

Q5R212

UniProtKB/TrEMBL

A6I1V5, F1LLW4

Related

ENSRNOP00000104501.1, ENSRNOT00000163821.1

Conserved Domains (1) summary

cl21584
Location:138 → 174

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...