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    Prr5 proline rich 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315189, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prr5provided by RGD
    Official Full Name
    proline rich 5provided by RGD
    Primary source
    RGD:1307954
    See related
    EnsemblRapid:ENSRNOG00000076724 AllianceGenome:RGD:1307954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Protor1
    Summary
    Predicted to be involved in TORC2 signaling. Predicted to act upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5 (proline rich 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 47.6), Spleen (RPKM 21.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prr5 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117675308..117717833)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115795351..115837880)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125569791..125609340)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene basic transcription factor 3 like 6 Neighboring gene Rho GTPase activating protein 8 Neighboring gene PHD finger protein 21B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Pearce LR, et al. Biochem J, 2011 May 15. PMID 21413931
    2. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
    3. mTOR signaling in growth control and disease. Laplante M, et al. Cell, 2012 Apr 13. PMID 22500797, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC109513

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich protein 5
    Names
    proline rich 5 (renal)
    protein observed with Rictor-1
    protor-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012121.1 → NP_001012121.1  proline-rich protein 5

      See identical proteins and their annotated locations for NP_001012121.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090007
      UniProtKB/Swiss-Prot
      Q5FVG6
      Conserved Domains (2) summary
      PHA03326
      Location:224 → 326
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:40 → 159
      HbrB; HbrB-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      117675308..117717833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765726.3 → XP_008763948.1  proline-rich protein 5 isoform X2

      See identical proteins and their annotated locations for XP_008763948.1

      UniProtKB/TrEMBL
      A0A0H2UHJ6
      Related
      ENSRNOP00000112692.1, ENSRNOT00000151946.1
      Conserved Domains (2) summary
      PHA03326
      Location:215 → 317
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:31 → 150
      HbrB; HbrB-like

    2. XM_063263625.1 → XP_063119695.1  proline-rich protein 5 isoform X2

    3. XM_017594872.3 → XP_017450361.1  proline-rich protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHJ6
      Conserved Domains (2) summary
      PHA03326
      Location:215 → 317
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:31 → 150
      HbrB; HbrB-like

    4. XM_008765722.4 → XP_008763944.1  proline-rich protein 5 isoform X2

      See identical proteins and their annotated locations for XP_008763944.1

      UniProtKB/TrEMBL
      A0A0H2UHJ6
      Conserved Domains (2) summary
      PHA03326
      Location:215 → 317
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:31 → 150
      HbrB; HbrB-like

    5. XM_039079293.2 → XP_038935221.1  proline-rich protein 5 isoform X1

      Conserved Domains (2) summary
      PHA03326
      Location:221 → 323
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:40 → 159
      HbrB; HbrB-like

    6. XM_008765723.4 → XP_008763945.1  proline-rich protein 5 isoform X3

      See identical proteins and their annotated locations for XP_008763945.1

      UniProtKB/TrEMBL
      A6HTC1
      Conserved Domains (2) summary
      PHA03326
      Location:128 → 230
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:1 → 63
      HbrB; HbrB-like

    7. XM_008765725.4 → XP_008763947.1  proline-rich protein 5 isoform X3

      See identical proteins and their annotated locations for XP_008763947.1

      UniProtKB/TrEMBL
      A6HTC1
      Conserved Domains (2) summary
      PHA03326
      Location:128 → 230
      PHA03326; nuclear egress membrane protein; Provisional
      pfam08539
      Location:1 → 63
      HbrB; HbrB-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVG6.1 GenPept UniProtKB/Swiss-Prot:Q5FVG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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