Fbxo43 F-box protein 43 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxo43provided by RGD
Official Full Name: F-box protein 43provided by RGD
Primary source: RGD:1310225
See related: EnsemblRapid:ENSRNOG00000010459 AllianceGenome:RGD:1310225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of meiotic nuclear division and regulation of mitotic nuclear division. Predicted to act upstream of or within negative regulation of protein catabolic process and regulation of meiotic nuclear division. Predicted to be located in female germ cell nucleus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 68.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (69218298..69231873, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (67333161..67346751, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (74925091..74938796, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box only protein 43

Names: endogenous meiotic inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.