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    Best3 bestrophin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314847, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Best3provided by RGD
    Official Full Name
    bestrophin 3provided by RGD
    Primary source
    RGD:1305439
    See related
    EnsemblRapid:ENSRNOG00000005491 AllianceGenome:RGD:1305439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vmd2l3
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to act upstream of or within chloride transmembrane transport and negative regulation of monoatomic ion transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human BEST3 (bestrophin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 27.0), Kidney (RPKM 3.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Best3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54471938..54548885)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52586824..52656776)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59971084..60057162)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene H3.3 histone A, pseudogene 5 Neighboring gene RAB3A interacting protein Neighboring gene uncharacterized LOC134479874 Neighboring gene uncharacterized LOC120093598 Neighboring gene uncharacterized LOC120093599 Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells. Jiang L, et al. Apoptosis, 2013 May. PMID 23468120
    2. Bestrophin-3 (vitelliform macular dystrophy 2-like 3 protein) is essential for the cGMP-dependent calcium-activated chloride conductance in vascular smooth muscle cells. Matchkov VV, et al. Circ Res, 2008 Oct 10. PMID 18776041
    3. A short motif in the C-terminus of mouse bestrophin 3 [corrected] inhibits its activation as a Cl channel. Qu Z, et al. FEBS Lett, 2006 Apr 3. PMID 16563389
    4. Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries. Broegger T, et al. Cardiovasc Res, 2011 Sep 1. PMID 21498420
    5. ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP. Lee WK, et al. Biochim Biophys Acta, 2012 Oct. PMID 22705154

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Best-3 inhibits apoptosis induced by H2O2 in basilar artery smooth muscle cells through mitochondria dependent pathway.
      Title: Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells.
    2. ERK1/2-dependent Best-3 activation regulates cell fate decisions during endoplasmic reticulum stress by suppressing CHOP induction and death.
      Title: ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP.
    3. Bestrophin-3 expression was significantly reduced compared with arteries transfected with mutated siRNA
      Title: Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.
    4. Bestrophin-3 (vitelliform macular dystrophy 2-like 3 protein) is essential for the cGMP-dependent calcium-activated chloride conductance in vascular smooth muscle cells.
      Title: Bestrophin-3 (vitelliform macular dystrophy 2-like 3 protein) is essential for the cGMP-dependent calcium-activated chloride conductance in vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ligand-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligand-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inorganic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of monoatomic ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bestrophin-3
    Names
    vitelliform macular dystrophy 2-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191783.1 → NP_001178712.1  bestrophin-3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4AAW7
      Related
      ENSRNOP00000007309.5, ENSRNOT00000007309.8
      Conserved Domains (1) summary
      pfam01062
      Location:8 → 316
      Bestrophin; RFP-TM, chloride channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54471938..54548885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079123.2 → XP_038935051.1  bestrophin-3 isoform X1

      Conserved Domains (1) summary
      pfam01062
      Location:91 → 388
      Bestrophin; RFP-TM, chloride channel

    2. XM_063263486.1 → XP_063119556.1  bestrophin-3 isoform X5

    3. XM_063263485.1 → XP_063119555.1  bestrophin-3 isoform X3

    4. XM_017594849.3 → XP_017450338.1  bestrophin-3 isoform X2

      UniProtKB/TrEMBL
      D4AAW7
      Conserved Domains (1) summary
      pfam01062
      Location:8 → 316
      Bestrophin; RFP-TM, chloride channel

    5. XM_017594851.3 → XP_017450340.1  bestrophin-3 isoform X4

      Related
      ENSRNOP00000112442.1, ENSRNOT00000173639.1
      Conserved Domains (1) summary
      pfam01062
      Location:41 → 274
      Bestrophin; RFP-TM, chloride channel

    6. XM_039079124.2 → XP_038935052.1  bestrophin-3 isoform X4

      Conserved Domains (1) summary
      pfam01062
      Location:41 → 274
      Bestrophin; RFP-TM, chloride channel
    Nucleotide Protein Strain
    Heading Accession and Version

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