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    Cdk17 cyclin-dependent kinase 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314743, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdk17provided by RGD
    Official Full Name
    cyclin-dependent kinase 17provided by RGD
    Primary source
    RGD:1565593
    See related
    EnsemblRapid:ENSRNOG00000004148 AllianceGenome:RGD:1565593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pctk2; Pctaire2
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK17 (cyclin dependent kinase 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 189.0), Lung (RPKM 151.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk17 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (29570982..29677613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (27683890..27765814)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34001506..34088418)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093552 Neighboring gene cilia and flagella associated protein 54 Neighboring gene uncharacterized LOC134479658 Neighboring gene uncharacterized LOC102548950 Neighboring gene ETS transcription factor ELK3 Neighboring gene uncharacterized LOC134479659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Hirose T, et al. Eur J Biochem, 2000 Apr. PMID 10727952
    2. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Hirose T, et al. Eur J Biochem, 1997 Oct 15. PMID 9370357
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 17
    Names
    PCTAIRE protein kinase 2
    PCTAIRE-motif protein kinase 2
    cell division protein kinase 17
    serine/threonine-protein kinase PCTAIRE-2
    NP_001101552.2
    XP_006241315.1
    XP_017450324.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108082.2 → NP_001101552.2  cyclin-dependent kinase 17

      See identical proteins and their annotated locations for NP_001101552.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O35831
      UniProtKB/TrEMBL
      A6IFX6, G3V6J5
      Related
      ENSRNOP00000005762.4, ENSRNOT00000005762.6
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      29570982..29677613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241253.5 → XP_006241315.1  cyclin-dependent kinase 17 isoform X2

      UniProtKB/Swiss-Prot
      O35831
      Related
      ENSRNOP00000112351.1, ENSRNOT00000123704.1
      Conserved Domains (2) summary
      cd07872
      Location:201 → 509
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
      PLN00009
      Location:205 → 493
      PLN00009; cyclin-dependent kinase A; Provisional

    2. XM_017594835.3 → XP_017450324.2  cyclin-dependent kinase 17 isoform X1

      UniProtKB/TrEMBL
      A6IFX5
      Related
      ENSRNOP00000085940.2, ENSRNOT00000109496.2

    RNA

    1. XR_001838688.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35831.1 GenPept UniProtKB/Swiss-Prot:O35831

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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