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    Chst11 carbohydrate sulfotransferase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314694, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Chst11provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 11provided by RGD
    Primary source
    RGD:1308400
    See related
    EnsemblRapid:ENSRNOG00000008885 AllianceGenome:RGD:1308400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C4ST1
    Summary
    Predicted to enable N-acetylgalactosamine 4-O-sulfotransferase activity; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; and chondroitin 4-sulfotransferase activity. Predicted to be involved in proteoglycan biosynthetic process. Predicted to act upstream of or within several processes, including chondroitin sulfate biosynthetic process; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in Golgi membrane. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 42.0), Thymus (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst11 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22412121..22630577, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20524535..20743008, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26641856..26890503, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550067 Neighboring gene solute carrier family 41 member 2 Neighboring gene uncharacterized LOC134479650 Neighboring gene uncharacterized LOC120093545 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479651 Neighboring gene uncharacterized LOC134479652 Neighboring gene thioredoxin reductase 1 Neighboring gene EP300 interacting inhibitor of differentiation 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of chondroitin 4-sulfotransferase. Yamauchi S, et al. J Biol Chem, 2000 Mar 24. PMID 10722746
    2. Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Izumikawa T, et al. Biochem J, 2011 Mar 1. PMID 21138417
    3. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. Okuda T, et al. J Biochem, 2000 Nov. PMID 11056388
    4. Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Klüppel M, et al. Development, 2005 Sep. PMID 16079159
    5. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylgalactosamine 4-O-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine 4-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chondroitin 4-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chondroitin 4-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chondrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in developmental growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within developmental growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic viscerocranium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polysaccharide localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polysaccharide localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-anal tail morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-anal tail morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 11
    Names
    C4S-1
    C4ST
    C4ST-1
    carbohydrate (chondroitin 4) sulfotransferase 11
    chondroitin 4-O-sulfotransferase 1
    chondroitin 4-sulfotransferase 1
    NP_001101549.1
    XP_006241262.1
    XP_038934963.1
    XP_038934964.1
    XP_063119507.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108079.1 → NP_001101549.1  carbohydrate sulfotransferase 11

      See identical proteins and their annotated locations for NP_001101549.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/Swiss-Prot
      P69478
      UniProtKB/TrEMBL
      A6IFH2
      Related
      ENSRNOP00000012017.9, ENSRNOT00000012017.7
      Conserved Domains (1) summary
      pfam03567
      Location:113 → 343
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22412121..22630577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241200.5 → XP_006241262.1  carbohydrate sulfotransferase 11 isoform X1

      See identical proteins and their annotated locations for XP_006241262.1

      UniProtKB/TrEMBL
      A0A8L2Q5L8
      Conserved Domains (1) summary
      pfam03567
      Location:108 → 338
      Sulfotransfer_2; Sulfotransferase family

    2. XM_063263437.1 → XP_063119507.1  carbohydrate sulfotransferase 11 isoform X3

      Related
      ENSRNOP00000109331.1, ENSRNOT00000160751.1

    3. XM_039079035.2 → XP_038934963.1  carbohydrate sulfotransferase 11 isoform X2

      Related
      ENSRNOP00000100407.1, ENSRNOT00000130475.1
      Conserved Domains (1) summary
      pfam03567
      Location:95 → 325
      Sulfotransfer_2; Sulfotransferase family

    4. XM_039079036.2 → XP_038934964.1  carbohydrate sulfotransferase 11 isoform X4

      Conserved Domains (1) summary
      pfam03567
      Location:52 → 282
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69478.1 GenPept UniProtKB/Swiss-Prot:P69478

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