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    Dohh deoxyhypusine hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314644, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dohhprovided by RGD
    Official Full Name
    deoxyhypusine hydroxylaseprovided by RGD
    Primary source
    RGD:1304783
    See related
    EnsemblRapid:ENSRNOG00000004259 AllianceGenome:RGD:1304783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304783
    Summary
    Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Predicted to be involved in peptidyl-lysine modification to peptidyl-hypusine. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 135.6), Brain (RPKM 106.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dohh in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8972202..8977025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8321466..8326305, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11191127..11195971, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 24 Neighboring gene small integral membrane protein 44 Neighboring gene fizzy and cell division cycle 20 related 1 Neighboring gene tektin bundle interacting protein 1 Neighboring gene major facilitator superfamily domain containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination. Han Z, et al. Structure, 2015 May 5. PMID 25865244
    2. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. Vu VV, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706422, Free PMC Article
    3. Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. Kim YS, et al. J Biol Chem, 2006 May 12. PMID 16533814, Free PMC Article
    4. A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation. Sievert H, et al. Dis Model Mech, 2014 Aug. PMID 24832488, Free PMC Article
    5. Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A. Kang KR, et al. J Biol Chem, 2007 Mar 16. PMID 17213197, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deoxyhypusine monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyhypusine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deoxyhypusine monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine modification to peptidyl-hypusine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine modification to peptidyl-hypusine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    deoxyhypusine hydroxylase
    Names
    deoxyhypusine dioxygenase
    deoxyhypusine hydroxylase/monooxygenase
    deoxyhypusine monooxygenase
    NP_001020177.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025006.2 → NP_001020177.1  deoxyhypusine hydroxylase

      See identical proteins and their annotated locations for NP_001020177.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5PPJ4
      UniProtKB/TrEMBL
      A0A8L2Q272
      Related
      ENSRNOP00000005640.5, ENSRNOT00000005640.8
      Conserved Domains (3) summary
      smart00567
      Location:52 → 80
      EZ_HEAT; E-Z type HEAT repeats
      pfam13646
      Location:7 → 96
      HEAT_2; HEAT repeats
      sd00044
      Location:39 → 67
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8972202..8977025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPJ4.1 GenPept UniProtKB/Swiss-Prot:Q5PPJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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