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    Stk11 serine/threonine kinase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314621, updated on 14-Nov-2024

    Summary

    Official Symbol
    Stk11provided by RGD
    Official Full Name
    serine/threonine kinase 11provided by RGD
    Primary source
    RGD:1308653
    See related
    EnsemblRapid:ENSRNOG00000014287 AllianceGenome:RGD:1308653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lkb1
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of gluconeogenesis; response to glucagon; and response to thyroid hormone. Located in Z disc. Part of protein-containing complex. Biomarker of hyperthyroidism and obesity. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 222.0), Muscle (RPKM 176.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stk11 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10225204..10241965, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9574553..9591315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12440751..12457513, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene midnolin Neighboring gene ATP synthase F1 subunit delta Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene uncharacterized LOC134479811 Neighboring gene strawberry notch homolog 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucagon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to thyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of intracellular protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of serine/threonine protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase STK11
    Names
    liver kinase B1 homolog
    serine/threonine-protein kinase 11
    serine/threonine-protein kinase LKB1
    NP_001101539.1
    XP_008763318.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108069.3NP_001101539.1  serine/threonine-protein kinase STK11

      See identical proteins and their annotated locations for NP_001101539.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      A0A0H2UI02, D4A179, D4AE59
      UniProtKB/TrEMBL
      A6K8R3
      Related
      ENSRNOP00000109626.1, ENSRNOT00000138015.1
      Conserved Domains (1) summary
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10225204..10241965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765096.2XP_008763318.1  serine/threonine-protein kinase STK11 isoform X1

      See identical proteins and their annotated locations for XP_008763318.1

      UniProtKB/Swiss-Prot
      A0A0H2UI02, D4A179, D4AE59
      UniProtKB/TrEMBL
      A6K8R3
      Conserved Domains (1) summary
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

    RNA

    1. XR_010052966.1 RNA Sequence

      Related
      ENSRNOT00000060683.5
    2. XR_005486597.2 RNA Sequence