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    Uvssa UV-stimulated scaffold protein A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314061, updated on 2-Nov-2024

    Summary

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    Symbol
    Uvssaprovided by RGD
    Full Name
    UV-stimulated scaffold protein Aprovided by RGD
    Primary source
    RGD:1306371
    See related
    EnsemblRapid:ENSRNOG00000005122 AllianceGenome:RGD:1306371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306371
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in protein ubiquitination; response to UV; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in UV-sensitive syndrome. Orthologous to human UVSSA (UV stimulated scaffold protein A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 38.6), Thymus (RPKM 37.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uvssa in Genome Data Viewer
    Location:
    14q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81535179..81576444, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77309188..77351922, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82621028..82658912, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 3, pseudogene 5 Neighboring gene NK1 homeobox 1 Neighboring gene uncharacterized LOC134481860 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene uncharacterized LOC134481861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nakazawa Y, et al. Nat Genet, 2012 May. PMID 22466610
    2. UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Schwertman P, et al. Nat Genet, 2012 May. PMID 22466611
    3. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Zhang X, et al. Nat Genet, 2012 May. PMID 22466612
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UV-stimulated scaffold protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134558.1 → NP_001128030.1  UV-stimulated scaffold protein A

      See identical proteins and their annotated locations for NP_001128030.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A0A096P6L4
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81535179..81576444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251323.5 → XP_006251385.1  UV-stimulated scaffold protein A isoform X1

      See identical proteins and their annotated locations for XP_006251385.1

      UniProtKB/Swiss-Prot
      D3ZND0
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    2. XM_063273306.1 → XP_063129376.1  UV-stimulated scaffold protein A isoform X2

    3. XM_006251325.5 → XP_006251387.1  UV-stimulated scaffold protein A isoform X1

      See identical proteins and their annotated locations for XP_006251387.1

      UniProtKB/Swiss-Prot
      D3ZND0
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    4. XM_006251321.5 → XP_006251383.1  UV-stimulated scaffold protein A isoform X1

      See identical proteins and their annotated locations for XP_006251383.1

      UniProtKB/Swiss-Prot
      D3ZND0
      Related
      ENSRNOP00000099106.1, ENSRNOT00000151963.1
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    5. XM_039092137.2 → XP_038948065.1  UV-stimulated scaffold protein A isoform X3

      Conserved Domains (1) summary
      pfam09740
      Location:395 → 498
      DUF2043; Uncharacterized conserved protein (DUF2043)

    6. XM_039092133.2 → XP_038948061.1  UV-stimulated scaffold protein A isoform X1

      UniProtKB/Swiss-Prot
      D3ZND0
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    7. XM_063273304.1 → XP_063129374.1  UV-stimulated scaffold protein A isoform X2

      Related
      ENSRNOP00000112232.1, ENSRNOT00000161304.1

    8. XM_006251324.5 → XP_006251386.1  UV-stimulated scaffold protein A isoform X1

      See identical proteins and their annotated locations for XP_006251386.1

      UniProtKB/Swiss-Prot
      D3ZND0
      Conserved Domains (1) summary
      pfam09740
      Location:508 → 611
      DUF2043; Uncharacterized conserved protein (DUF2043)

    9. XM_063273308.1 → XP_063129378.1  UV-stimulated scaffold protein A isoform X2

    10. XM_063273305.1 → XP_063129375.1  UV-stimulated scaffold protein A isoform X2

      Related
      ENSRNOP00000006841.7, ENSRNOT00000006841.7

    11. XM_039092140.2 → XP_038948068.1  UV-stimulated scaffold protein A isoform X5

      Conserved Domains (1) summary
      pfam09740
      Location:508 → 533
      DUF2043; Uncharacterized conserved protein (DUF2043)

    12. XM_039092138.2 → XP_038948066.1  UV-stimulated scaffold protein A isoform X4

      Conserved Domains (1) summary
      pfam09740
      Location:508 → 532
      DUF2043; Uncharacterized conserved protein (DUF2043)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZND0.2 GenPept UniProtKB/Swiss-Prot:D3ZND0

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