Olfm2 olfactomedin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olfm2provided by RGD
Official Full Name: olfactomedin 2provided by RGD
Primary source: RGD:1309741
See related: EnsemblRapid:ENSRNOG00000020519 AllianceGenome:RGD:1309741
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in regulation of vascular associated smooth muscle cell dedifferentiation. Predicted to be located in several cellular components, including extracellular region; nucleoplasm; and synaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space and glutamatergic synapse. Predicted to be extrinsic component of postsynaptic density membrane. Orthologous to human OLFM2 (olfactomedin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 50.0), Adrenal (RPKM 6.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27480703..27558416, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19204472..19282154, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (21684307..21762000, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olfactomedin 2 regulates vascular smooth muscle phenotype and vascular remodeling by regulating Runx2/serum response factor interaction.
Title: Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor.
Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development.
Title: Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.

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General gene information

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Markers

Olfm2 (e-PCR), detects polymorphism
- UniSTS:534579

Olfm2 (e-PCR), detects polymorphism
- UniSTS:534580

D8Got19 (e-PCR)
- UniSTS:112224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular associated smooth muscle cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: noelin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.