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    Dnai4 dynein axonemal intermediate chain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313417, updated on 2-Nov-2024

    Summary

    Official Symbol
    Dnai4provided by RGD
    Official Full Name
    dynein axonemal intermediate chain 4provided by RGD
    Primary source
    RGD:1311027
    See related
    EnsemblRapid:ENSRNOG00000006999 AllianceGenome:RGD:1311027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr78; RGD1311027
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 137.3), Thymus (RPKM 89.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnai4 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (123016480..123105283, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (117787398..117876216, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122551370..122642161, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene insulin like 5 Neighboring gene MIER1 transcriptional regulator Neighboring gene solute carrier family 35 member D1 Neighboring gene similar to human chromosome 1 open reading frame 141

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of axonemal dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of axonemal dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of axonemal dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dynein axonemal particle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dynein axonemal intermediate chain 4
    Names
    WD repeat domain 78
    WD repeat-containing protein 78
    dynein intermediate chain 4, axonemal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024786.2NP_001019957.1  dynein axonemal intermediate chain 4

      See identical proteins and their annotated locations for NP_001019957.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q4V8G4, Q5XIP5
      UniProtKB/TrEMBL
      A0A8L2QPC1
      Related
      ENSRNOP00000089481.2, ENSRNOT00000115287.2
      Conserved Domains (3) summary
      COG2319
      Location:443781
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:497541
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:496778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      123016480..123105283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287692.1XP_063143762.1  dynein axonemal intermediate chain 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B2X4
    2. XM_063287690.1XP_063143760.1  dynein axonemal intermediate chain 4 isoform X1

      Related
      ENSRNOP00000100351.1, ENSRNOT00000127153.1
    3. XM_063287691.1XP_063143761.1  dynein axonemal intermediate chain 4 isoform X2

      Related
      ENSRNOP00000106569.1, ENSRNOT00000129945.1
    4. XM_008763872.3XP_008762094.1  dynein axonemal intermediate chain 4 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QPC1
      Related
      ENSRNOP00000095528.2, ENSRNOT00000117003.2
      Conserved Domains (3) summary
      COG2319
      Location:443764
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:498541
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:496747
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_039109947.2XP_038965875.1  dynein axonemal intermediate chain 4 isoform X5

      Conserved Domains (2) summary
      COG2319
      Location:114454
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:168212
      7WD40; WD40 repeat [structural motif]