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    Sgip1 SH3GL interacting endocytic adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sgip1provided by RGD
    Official Full Name
    SH3GL interacting endocytic adaptor 1provided by RGD
    Primary source
    RGD:1564957
    See related
    EnsemblRapid:ENSRNOG00000006357 AllianceGenome:RGD:1564957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564957
    Summary
    Enables tubulin binding activity. Involved in several processes, including positive regulation of eating behavior; response to dietary excess; and response to starvation. Located in terminal bouton. Is active in presynapse. Orthologous to human SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 158.3), Lung (RPKM 35.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgip1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (122755216..122963677)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (117536752..117734593)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122300415..122498478)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B Neighboring gene uncharacterized LOC103692427 Neighboring gene uncharacterized LOC102548249 Neighboring gene uncharacterized LOC134486957 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene dynein light chain Tctex-type family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner. Hájková A, et al. Neuropharmacology, 2016 Aug. PMID 26970018
    2. Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership. Gortat A, et al. J Biol Chem, 2012 Feb 3. PMID 22167186, Free PMC Article
    3. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. Trevaskis J, et al. Endocrinology, 2005 Sep. PMID 15919751
    4. Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. Dergai O, et al. Biochem Biophys Res Commun, 2010 Nov 12. PMID 20946875
    5. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. Uezu A, et al. J Biol Chem, 2007 Sep 7. PMID 17626015

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AP-2 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton HDA PubMed 

    General protein information

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    Preferred Names
    SH3-containing GRB2-like protein 3-interacting protein 1
    Names
    Endophilin-3-interacting protein
    SH3-domain GRB2-like (endophilin) interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376936.1 → NP_001363865.1  SH3-containing GRB2-like protein 3-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1M1Y0
      Related
      ENSRNOP00000109027.1, ENSRNOT00000143443.1
      Conserved Domains (1) summary
      cd09266
      Location:588 → 854
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      122755216..122963677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287659.1 → XP_063143729.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GCF4
      Related
      ENSRNOP00000059906.5, ENSRNOT00000064567.6

    2. XM_063287674.1 → XP_063143744.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

    3. XM_063287665.1 → XP_063143735.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

    4. XM_063287678.1 → XP_063143748.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X24

    5. XM_063287680.1 → XP_063143750.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X26

    6. XM_063287682.1 → XP_063143752.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X28

    7. XM_063287684.1 → XP_063143754.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X29

    8. XM_063287653.1 → XP_063143723.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      Related
      ENSRNOP00000101313.1, ENSRNOT00000169322.1

    9. XM_063287661.1 → XP_063143731.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GCF4
      Related
      ENSRNOP00000096859.2, ENSRNOT00000106500.2

    10. XM_063287654.1 → XP_063143724.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      Related
      ENSRNOP00000085071.2, ENSRNOT00000100702.2

    11. XM_063287657.1 → XP_063143727.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

      Related
      ENSRNOP00000106186.1, ENSRNOT00000171153.1

    12. XM_063287656.1 → XP_063143726.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

    13. XM_063287658.1 → XP_063143728.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

    14. XM_063287672.1 → XP_063143742.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

    15. XM_063287673.1 → XP_063143743.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

    16. XM_063287655.1 → XP_063143725.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

    17. XM_063287686.1 → XP_063143756.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X31

    18. XM_039109937.2 → XP_038965865.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

      Conserved Domains (1) summary
      cd09266
      Location:366 → 632
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    19. XM_063287662.1 → XP_063143732.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

    20. XM_063287664.1 → XP_063143734.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

    21. XM_063287688.1 → XP_063143758.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X33

      Related
      ENSRNOP00000095822.1, ENSRNOT00000110115.2

    22. XM_063287689.1 → XP_063143759.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X34

    23. XM_063287685.1 → XP_063143755.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X30

    24. XM_063287666.1 → XP_063143736.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

      Related
      ENSRNOP00000106924.1, ENSRNOT00000129393.1

    25. XM_063287687.1 → XP_063143757.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X32

    26. XM_039109938.2 → XP_038965866.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

      Conserved Domains (1) summary
      cd09266
      Location:362 → 628
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    27. XM_039109940.2 → XP_038965868.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

      Conserved Domains (1) summary
      cd09266
      Location:342 → 608
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    28. XM_063287676.1 → XP_063143746.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

    29. XM_063287677.1 → XP_063143747.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X23

    30. XM_063287679.1 → XP_063143749.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X25

    31. XM_063287681.1 → XP_063143751.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X27

    32. XM_063287663.1 → XP_063143733.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

    33. XM_063287667.1 → XP_063143737.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

    34. XM_063287675.1 → XP_063143745.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

    35. XM_063287669.1 → XP_063143739.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

    36. XM_063287670.1 → XP_063143740.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    37. XM_063287671.1 → XP_063143741.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

    38. XM_063287668.1 → XP_063143738.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

      Related
      ENSRNOP00000082178.2, ENSRNOT00000095642.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DJJ3.1 GenPept UniProtKB/Swiss-Prot:P0DJJ3

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