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    Hdhd5 haloacid dehalogenase like hydrolase domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312680, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hdhd5provided by RGD
    Official Full Name
    haloacid dehalogenase like hydrolase domain containing 5provided by RGD
    Primary source
    RGD:1306557
    See related
    EnsemblRapid:ENSRNOG00000011338 AllianceGenome:RGD:1306557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cecr5
    Summary
    Predicted to be involved in glycerophospholipid biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human HDHD5 (haloacid dehalogenase like hydrolase domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 131.7), Kidney (RPKM 66.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hdhd5 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155372781..155425496, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153701026..153753303, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153046701..153079065, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor A Neighboring gene transmembrane protein 121B Neighboring gene uncharacterized LOC108350753 Neighboring gene CECR2, histone acetyl-lysine reader

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in glycerophospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing 5
    Names
    cat eye syndrome chromosome region, candidate 5 homolog
    cat eye syndrome critical region protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107884.1 → NP_001101354.1  haloacid dehalogenase-like hydrolase domain-containing 5

      See identical proteins and their annotated locations for NP_001101354.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A0A8I6A520, A6ILA7
      Conserved Domains (2) summary
      TIGR01456
      Location:47 → 358
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
      pfam13344
      Location:49 → 152
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155372781..155425496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107661.2 → XP_038963589.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

      Conserved Domains (1) summary
      TIGR01456
      Location:47 → 315
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    2. XM_006237247.5 → XP_006237309.2  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X2

      Conserved Domains (1) summary
      TIGR01456
      Location:47 → 315
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    3. XM_063286119.1 → XP_063142189.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X3

      UniProtKB/TrEMBL
      D3ZQB6
      Related
      ENSRNOP00000015090.7, ENSRNOT00000015090.7

    4. XM_006237246.5 → XP_006237308.2  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A520
      Related
      ENSRNOP00000085914.1, ENSRNOT00000112876.2
    Nucleotide Protein Strain
    Heading Accession and Version

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