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    Sel1l2 SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sel1l2provided by RGD
    Official Full Name
    SEL1L2 adaptor subunit of SYVN1 ubiquitin ligaseprovided by RGD
    Primary source
    RGD:1311278
    See related
    EnsemblRapid:ENSRNOG00000004852 AllianceGenome:RGD:1311278
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311278
    Summary
    Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SEL1L2 (SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 49.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sel1l2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (148040624..148167490, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (127586031..127713857, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (134281809..134406560, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene U6 spliceosomal RNA Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene fibronectin leucine rich transmembrane protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein sel-1 homolog 2
    Names
    SEL1L2 ERAD E3 ligase adaptor subunit
    SEL1L2 adaptor subunit of ERAD E3 ligase
    SEL1L2 adaptor subunit of ERAD E3 ubiquitin ligase
    sel-1 suppressor of lin-12-like 2
    sel-1L2
    suppressor of lin-12-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014049.1 → NP_001014071.1  protein sel-1 homolog 2 precursor

      See identical proteins and their annotated locations for NP_001014071.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083893
      UniProtKB/Swiss-Prot
      Q5XI05
      UniProtKB/TrEMBL
      A0A0G2K489
      Related
      ENSRNOP00000036379.7, ENSRNOT00000033562.8
      Conserved Domains (4) summary
      smart00671
      Location:407 → 441
      SEL1; Sel1-like repeats
      COG0790
      Location:151 → 445
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:317 → 346
      SLR; SLR repeat [structural motif]
      pfam08238
      Location:371 → 405
      Sel1; Sel1 repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      148040624..148167490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283797.1 → XP_063139867.1  protein sel-1 homolog 2 isoform X9

    2. XM_039105034.2 → XP_038960962.1  protein sel-1 homolog 2 isoform X6

      UniProtKB/TrEMBL
      A6HQM2
      Conserved Domains (2) summary
      COG0790
      Location:274 → 550
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:242 → 271
      SLR; SLR repeat [structural motif]

    3. XM_039105031.2 → XP_038960959.1  protein sel-1 homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K489
      Conserved Domains (3) summary
      COG0790
      Location:329 → 605
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:297 → 326
      SLR; SLR repeat [structural motif]
      pfam08238
      Location:280 → 312
      Sel1; Sel1 repeat

    4. XM_063283794.1 → XP_063139864.1  protein sel-1 homolog 2 isoform X5

    5. XM_039105033.2 → XP_038960961.1  protein sel-1 homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K489
      Conserved Domains (2) summary
      COG0790
      Location:310 → 576
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:341 → 370
      SLR; SLR repeat [structural motif]

    6. XM_039105030.2 → XP_038960958.1  protein sel-1 homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K489
      Conserved Domains (2) summary
      COG0790
      Location:348 → 624
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:353 → 382
      SLR; SLR repeat [structural motif]

    7. XM_039105029.2 → XP_038960957.1  protein sel-1 homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K489
      Related
      ENSRNOP00000072949.3, ENSRNOT00000081589.3
      Conserved Domains (2) summary
      COG0790
      Location:349 → 625
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:317 → 346
      SLR; SLR repeat [structural motif]

    8. XM_063283795.1 → XP_063139865.1  protein sel-1 homolog 2 isoform X7

    9. XM_039105035.2 → XP_038960963.1  protein sel-1 homolog 2 isoform X8

      UniProtKB/TrEMBL
      A6HQM2
      Conserved Domains (2) summary
      COG0790
      Location:237 → 513
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:205 → 234
      SLR; SLR repeat [structural motif]

    10. XM_063283796.1 → XP_063139866.1  protein sel-1 homolog 2 isoform X8

    11. XM_039105036.2 → XP_038960964.1  protein sel-1 homolog 2 isoform X8

      UniProtKB/TrEMBL
      A6HQM2
      Conserved Domains (2) summary
      COG0790
      Location:237 → 513
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:205 → 234
      SLR; SLR repeat [structural motif]

    12. XM_039105038.2 → XP_038960966.1  protein sel-1 homolog 2 isoform X10

      Conserved Domains (2) summary
      COG0790
      Location:13 → 289
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:18 → 47
      SLR; SLR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI05.1 GenPept UniProtKB/Swiss-Prot:Q5XI05

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