Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tanc1provided by RGD
Official Full Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by RGD
Primary source: RGD:1302949
See related: EnsemblRapid:ENSRNOG00000025394 AllianceGenome:RGD:1302949
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tanc
Summary: Involved in regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 110.7), Lung (RPKM 56.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (64508037..64741826)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (44099387..44335478)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (45683773..45917687)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins.
Title: A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3RAT44 (e-PCR)
- UniSTS:121863

AU028276 (e-PCR)
- UniSTS:112484

AU048023 (e-PCR)
- UniSTS:109949

D3Rat187 (e-PCR), detects polymorphism
- UniSTS:227581

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein TANC1

Names: TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1; TPR domain, ankyrin-repeat and coiled-coil-containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002854.2 → NP_001002854.2 protein TANC1 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001431669.1 → NP_001418598.1 protein TANC1 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001431670.1 → NP_001418599.1 protein TANC1 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

64508037..64741826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283615.1 → XP_063139685.1 protein TANC1 isoform X1

UniProtKB/TrEMBL

A6JF67, G3V917
XM_006234204.4 → XP_006234266.1 protein TANC1 isoform X1

See identical proteins and their annotated locations for XP_006234266.1

UniProtKB/Swiss-Prot

Q6F6B3

UniProtKB/TrEMBL

A6JF67, G3V917

Related

ENSRNOP00000033136.6, ENSRNOT00000038983.7

Conserved Domains (5) summary

PHA03095
Location:903 → 1215

PHA03095; ankyrin-like protein; Provisional

COG0457
Location:1282 → 1413

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:1289 → 1314

TPR; TPR repeat [structural motif]

sd00045
Location:1142 → 1172

ANK; ANK repeat [structural motif]

pfam12796
Location:1113 → 1205

Ank_2; Ankyrin repeats (3 copies)
XM_017591681.3 → XP_017447170.1 protein TANC1 isoform X2

Related

ENSRNOP00000088260.1, ENSRNOT00000115662.2
XM_039104830.2 → XP_038960758.1 protein TANC1 isoform X1

UniProtKB/Swiss-Prot

Q6F6B3

UniProtKB/TrEMBL

A6JF67, G3V917

Conserved Domains (5) summary

PHA03095
Location:903 → 1215

PHA03095; ankyrin-like protein; Provisional

COG0457
Location:1282 → 1413

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:1289 → 1314

TPR; TPR repeat [structural motif]

sd00045
Location:1142 → 1172

ANK; ANK repeat [structural motif]

pfam12796
Location:1113 → 1205

Ank_2; Ankyrin repeats (3 copies)
XM_063283616.1 → XP_063139686.1 protein TANC1 isoform X2