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    ase asense [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 30985, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aseprovided by FlyBase
    Official Full Name
    asenseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000137
    Locus tag
    Dmel_CG3258
    See related
    AllianceGenome:FB:FBgn0000137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AS-C T8; AS-C T8ase; as-T8; AS-T8; ASC; ascT8; Ase; Asense; bHLHc28; CG3258; Dmel\CG3258; EG:165H7.2; sc/T8; T1; T1a; T1A; T8
    Summary
    Enables DNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; negative regulation of mitotic nuclear division; and neuroblast fate determination. Located in nucleus. Is expressed in several structures, including ganglia; imaginal disc; presumptive embryonic/larval system; sensory nervous system primordium; and somatic precursor cell. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1) and ASCL2 (achaete-scute family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ase in Genome Data Viewer
    Location:
    1B3-1B3; 1-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (460747..463176)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (354780..357209)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lethal of scute Neighboring gene Pepsinogen C-like Neighboring gene Cytochrome P450 4g1 Neighboring gene ellipsoid body open

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation and divergence of related neuronal lineages in the Drosophila central brain. Lee YJ, et al. Elife, 2020 Apr 7. PMID 32255422, Free PMC Article
    2. bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons. Hartenstein V, et al. Dev Biol, 2017 Nov 1. PMID 28751238, Free PMC Article
    3. A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells. Yasugi T, et al. PLoS One, 2014. PMID 24804774, Free PMC Article
    4. Restriction of Wolbachia Bacteria in Early Embryogenesis of Neotropical Drosophila Species via Endoplasmic Reticulum-Mediated Autophagy. Strunov A, et al. mBio, 2022 Apr 26. PMID 35357208, Free PMC Article
    5. Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Lyman DF, et al. Genetics, 1995 Dec. PMID 8601489, Free PMC Article

    See all (338) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.
      Title: A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.
    2. The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
      Title: The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
    3. Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
      Title: Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
    4. PntP1 is both necessary and sufficient for the suppression of Ase in type II NBs and the generation of intermediate neural progenitor cells in Drosophila larval brains
      Title: Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule tip cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peripheral nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asense
    Names
    CG3258-PA
    ase-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      460747..463176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057346.5 → NP_476694.1  asense [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09775, Q541C1, Q9W5G2
      Related
      FBpp0070074
      Conserved Domains (1) summary
      pfam00010
      Location:172 → 224
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09775.2 P09775

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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