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    ac achaete [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 30981, updated on 28-Oct-2024

    Summary

    Official Symbol
    acprovided by FlyBase
    Official Full Name
    achaeteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000022
    Locus tag
    Dmel_CG3796
    See related
    AllianceGenome:FB:FBgn0000022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    990 E5 F1; Ac; AC; Achaete; achaete-scute; AS-C; AS-C T5; AS-C T5ac; ASC; ascT5; CG3796; Dmel\CG3796; EG:125H10.3; Hw; sc/T5; T5
    Summary
    Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; chaeta morphogenesis; and positive regulation of antibacterial peptide biosynthetic process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including dorsocentral bristle; imaginal disc; neurogenic region; procephalic segment; and somatic precursor cell. Orthologous to several human genes including ASCL2 (achaete-scute family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    Location:
    1A6-1A6; 1-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (370031..370947)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (264064..264980)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene yellow-achaete intergenic RNA Neighboring gene long non-coding RNA:CR44751 Neighboring gene yellow Neighboring gene long non-coding RNA:CR44752

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Malpighian tubule tip cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaeta morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventral cord development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    achaete
    Names
    Achaete/Scute
    CG3796-PA
    Hairy-wing
    ac-PA
    achaete-scute
    acheate
    achete
    asc
    hairy wing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      370031..370947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057476.3NP_476824.1  achaete [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10083, Q4V702, Q9W5G4
      Related
      FBpp0070071
      Conserved Domains (1) summary
      cd19744
      Location:2594
      bHLH_TS_dAS-C_like; basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins