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    Gsto2 glutathione S-transferase omega 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309465, updated on 2-Nov-2024

    Summary

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    Symbol
    Gsto2provided by RGD
    Full Name
    glutathione S-transferase omega 2provided by RGD
    Primary source
    RGD:1310764
    See related
    EnsemblRapid:ENSRNOG00000069697 AllianceGenome:RGD:1310764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTO 2-2
    Summary
    Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 240.7), Adrenal (RPKM 50.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gsto2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256673376..256695154)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246731314..246757592)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267617517..267640455)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glutathione S-transferase omega 1 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene uncharacterized LOC120100050 Neighboring gene microRNA 3584 Neighboring gene cilia and flagella associated protein 58 Neighboring gene ribosomal protein L21 like 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Schmuck EM, et al. Pharmacogenet Genomics, 2005 Jul. PMID 15970797
    2. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li YJ, et al. Hum Mol Genet, 2003 Dec 15. PMID 14570706
    3. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Polimanti R, et al. Clin Exp Pharmacol Physiol, 2010 Aug. PMID 20374258
    4. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk A, et al. Neurobiol Aging, 2005 Aug-Sep. PMID 15917099
    5. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Wahner AD, et al. Neurosci Lett, 2007 Feb 21. PMID 17194543, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-ascorbic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ascorbic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to arsenic-containing substance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase omega-2
    Names
    GSTO-2
    MMA(V) reductase
    glutathione S-transferase omega 2-2
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_001012071.1
    NP_001406671.1
    XP_006231652.1
    XP_006231654.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012071.1 → NP_001012071.1  glutathione S-transferase omega-2

      See identical proteins and their annotated locations for NP_001012071.1

      Status: VALIDATED

      Source sequence(s)
      BC079295
      UniProtKB/Swiss-Prot
      Q6AXV9
      UniProtKB/TrEMBL
      A0A8L2Q9F9, B6DYQ6
      Related
      ENSRNOP00000017186.5, ENSRNOT00000017186.8
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:7 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_001419742.1 → NP_001406671.1  glutathione S-transferase omega-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6AXV9
      UniProtKB/TrEMBL
      B6DYQ6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      256673376..256695154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231592.3 → XP_006231654.1  glutathione S-transferase omega-2 isoform X1

      See identical proteins and their annotated locations for XP_006231654.1

      UniProtKB/Swiss-Prot
      Q6AXV9
      UniProtKB/TrEMBL
      A0A8L2Q9F9, B6DYQ6
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:7 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. XM_006231590.4 → XP_006231652.1  glutathione S-transferase omega-2 isoform X1

      See identical proteins and their annotated locations for XP_006231652.1

      UniProtKB/Swiss-Prot
      Q6AXV9
      UniProtKB/TrEMBL
      A0A8L2Q9F9, B6DYQ6
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:7 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXV9.1 GenPept UniProtKB/Swiss-Prot:Q6AXV9

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