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    Ptgdr2 prostaglandin D2 receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309212, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ptgdr2provided by RGD
    Official Full Name
    prostaglandin D2 receptor 2provided by RGD
    Primary source
    RGD:1311986
    See related
    EnsemblRapid:ENSRNOG00000090389 AllianceGenome:RGD:1311986
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr44
    Summary
    Predicted to enable neuropeptide binding activity and prostaglandin receptor activity. Predicted to be involved in calcium-mediated signaling; chemotaxis; and neuropeptide signaling pathway. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 83.4), Lung (RPKM 29.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptgdr2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (217010183..217015044)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207585088..207590275)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226976455..226995641)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 19 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene coiled-coil domain containing 86 Neighboring gene membrane spanning 4-domains A10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. Liu H, et al. Immunology, 2014 May. PMID 24329550, Free PMC Article
    2. COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. Kanda H, et al. Glia, 2013 Jun. PMID 23505121
    3. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Stearns BA, et al. Bioorg Med Chem Lett, 2009 Aug 15. PMID 19608418
    4. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Tirouvanziam R, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18334635, Free PMC Article
    5. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Kagawa S, et al. Int Arch Allergy Immunol, 2011. PMID 21646789

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy.
      Title: Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.
    2. Production of prostaglandin D2 followed by eosinophil recruitment into the airways via a CRTH2 receptor are the major pathogenic factors responsible for the A. fumigatus-induced enhancement of airway inflammation and responsiveness.
      Title: Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus.
    3. We believe that PGD2 signaling via DP2 signaling pathway from microglia to neurons is one of the triggering factors for mechanical allodynia in this neuropathic pain model.
      Title: COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin D receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin D receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin D receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prostaglandin F receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin J receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of male germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin D2 receptor 2
    Names
    G protein-coupled receptor 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012070.1 → NP_001012070.1  prostaglandin D2 receptor 2

      See identical proteins and their annotated locations for NP_001012070.1

      Status: PROVISIONAL

      Source sequence(s)
      AY228550
      UniProtKB/Swiss-Prot
      Q6XKD3
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32 → 314
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      217010183..217015044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264453.1 → XP_063120523.1  prostaglandin D2 receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6XKD3
      Related
      ENSRNOP00000104794.1, ENSRNOT00000153762.1

    2. XM_039079849.2 → XP_038935777.1  prostaglandin D2 receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6XKD3
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32 → 314
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_063264455.1 → XP_063120525.1  prostaglandin D2 receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6XKD3
      Related
      ENSRNOP00000066082.1, ENSRNOT00000054808.6

    4. XM_039079846.2 → XP_038935774.1  prostaglandin D2 receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6XKD3
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32 → 314
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_039079847.2 → XP_038935775.1  prostaglandin D2 receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6XKD3
      Related
      ENSRNOP00000102756.1, ENSRNOT00000128375.1
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32 → 314
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XKD3.1 GenPept UniProtKB/Swiss-Prot:Q6XKD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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